An efficient and reliable algorithm for computing the Euclidean distance between a pair of convex sets in R m is described. Extensive numerical experience with a broad family of polytopes in R 3 shows that the computational cost is approximately linear in the total number of vertices specifying the two polytopes. The algorithm has special features which makes its application in a variety of robotics problems attractive. These are discussed and an example of collision detection is given.
It is unclear what role the experimental drug and convalescent plasma had in the recovery of these patients. Prospective clinical trials are needed to delineate the role of investigational therapies in the care of patients with EVD.
Abstract-An efficient and reliable algorithm for computing the Euclidean distance between a pair of convex sets in R m is described.Extensive numerical experience with a broad family of polytopes in R 3 shows that the computational cost is approximately linear in the total number of vertices specifying the two polytopes. The algorithm has special features which makes its application in a variety of robotics problems attractive. These are discussed and an example of collision detection is given.
IntroductionA paucity of literature exists regarding delays in transfer out of the intensive care unit. We sought to analyze the incidence, causes, and costs of delayed transfer from a surgical intensive care unit (SICU).MethodsAn IRB-approved prospective observational study was conducted from January 24, 2010, to July 31, 2010, of all 731 patients transferred from a 20-bed SICU at a large tertiary-care academic medical center. Data were collected on patients who were medically ready for transfer to the floor who remained in the SICU for at least 1 extra day. Reasons for delay were examined, and extra costs associated were estimated.ResultsTransfer to the floor was delayed in 22% (n = 160) of the 731 patients transferred from the SICU. Delays ranged from 1 to 6 days (mean, 1.5 days; median, 2 days). The extra costs associated with delays were estimated to be $581,790 during the study period, or $21,547 per week. The most common reasons for delay in transfer were lack of available surgical-floor bed (71% (114 of 160)), lack of room appropriate for infectious contact precautions (18% (28 of 160)), change of primary service (Surgery to Medicine) (7% (11 of 160)), and lack of available patient attendant ("sitter" for mildly delirious patients) (3% (five of 160)). A positive association was found between the daily hospital census and the daily number of SICU beds occupied by patients delayed in transfer (Spearman rho = 0.27; P < 0.0001).ConclusionsDelay in transfer from the SICU is common and costly. The most common reason for delay is insufficient availability of surgical-floor beds. Delay in transfer is associated with high hospital census. Further study of this problem is necessary.
Survival discordance was not associated with differences in early goal-directed therapy bundle compliance or hemodynamic goal achievement. Our results suggest that it was associated with faster and more appropriate antibiotic co-intervention in the early goal-directed therapy arm compared with controls in the observational studies but not in the randomized trials. Early goal-directed therapy was associated with increased mortality in patients with high-disease severity.
Objective
This report describes three patients with Ebola virus disease who were treated in the United States and developed for severe critical illness and multiple organ failure secondary to Ebola virus infection. The patients received mechanical ventilation, renal replacement therapy, invasive monitoring, vasopressor support, and investigational therapies for Ebola virus disease.
Data Sources
Patient medical records from three tertiary care centers (Emory University Hospital, University of Nebraska Medical Center, and Texas Health Presbyterian Dallas Hospital).
Study Selection
Not applicable.
Data Extraction
Not applicable.
Data Synthesis
Not applicable.
Conclusion
In the severe form, patients with Ebola virus disease may require life-sustaining therapy, including mechanical ventilation and renal replacement therapy. In conjunction with other reported cases, this series suggests that respiratory and renal failure may occur in severe Ebola virus disease, especially in patients burdened with high viral loads. Ebola virus disease complicated by multiple organ failure can be survivable with the application of advanced life support measures. This collective, multicenter experience is presented with the hope that it may inform future treatment of patients with Ebola virus disease requiring critical care treatment.
The use of bacteria as a tool for machining, also known as biomachining, is a novel material removal process. This study characterizes the surface changes and relates the material removal rate to quantified bacterial concentrations resulting from machining of pure polycrystalline Cu using the bacterium Acidithiobacillus ferrooxidans. Cu blocks, polished to four levels of surface roughness, were utilized to examine the surface effects of bacterial machining. The mass change in Cu foil was measured to find the material removal rate. The most probable number method, a statistical enumeration technique, was applied to estimate bacterial concentrations. Scanning electron microscope (SEM) micrographs demonstrate that bacterial machining is anisotropic, and roughness measurements of the polycrystalline Cu samples showed a deterioration of Ra values of 1.5-2.5μm. Finally, suggestions for future work are presented that could potentially ameliorate current process problems.
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