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The world economy is sewed by a set of critical infrastnictures in oreas such as transportation, power, communication, water, and energl. In the past, injirostnrcture design used traditional engineering design approaches, w,hich focused primarily on the technical requirements. This paper describes how next generotion irfiastructures should be treated os large-scale complex engineering systems requiring different frameworks, methodologies and design principles. Next generotion iifrostiwcture development requires a holistic perspective which includes organizationol oiid contextuol factors in addition to technical foctors as on integro1 part af the design process. We propose dyerent design approqches. utilizing uncertainty management, which are based on sustainobilip a s . an over-arching design princijde. Particular attention in the poper is given to security considerotions and the development of self-monitoring intelligent infrostructure.