Although fascial biopsy has classically been considered the gold standard for making a diagnosis of EF, radiologic imaging, particularly magnetic resonance imaging, has been increasingly used for both diagnosis and monitoring of treatment response. Systemic corticosteroids remain the first-line treatment for EF; however, their often prolonged use in the treatment of EF has prompted a search for adjunctive therapies. Methotrexate has emerged as the leading corticosteroid-sparing agent for EF. Since EF was initially described over 40 years ago, important diagnostic and therapeutic progress has been made. Future efforts should be directed at the pursuit of prospective studies including clinical trials and evidence-based guidelines.

• Numerous techniques are required to provide optimal MR images in paediatric patients. • Radial free-breathing contrast-enhanced acquisition demonstrated excellent image quality. • Image quality and lesion conspicuity were better with radial than Cartesian acquisition. • More lesions were detected on contrast-enhanced radial than on Cartesian acquisition. • Radial GRE can be used for performing abdominopelvic MRI in paediatric patients.

Drs Hubiche and Valério had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

No abstract

Reactive infectious mucocutaneous eruption (RIME) was recently proposed to replace the term Mycoplasma pneumoniae (MP)‐induced rash and mucositis to account for the fact that non‐MP pathogens may also cause rash and mucositis. In this report, we describe a unique case of recurrent RIME featuring a total of three episodes. As two of the episodes demonstrated contemporaneous infection with MP and group A streptococcus or influenza B, this case lends further support to use of the term RIME. In addition, although RIME typically involves at least two mucous membranes, this case shows that recurrent episodes may fall into the rare exception in which mucositis is limited to one site.

A plausible origin of biomolecular homochirality is advanced, where alpha-methyl amino acids found on meteorites transfer their chirality in the synthesis of normal amino acids. This asymmetry can be amplified to nearly homochiral levels, thus providing the necessary prerequisite for life to start on this planet and elsewhere in the universe.

Overview of TikTok's most viewed dermatologic content and assessment of its reliabilityTo the Editor: Around 80% of people seek medical information online, and #45% report that social media influences their decisions to seek medical care. 1,2 With [2 billion total downloads, TikTok is the world's fastest growing social media platform. This popular app allows users to create and share short videos on numerous topics, including health care. Previous studies have analyzed the dermatologic content posted on Instagram, Twitter, and YouTube. 3 This study is the first to characterize the content, sources, and reliability of the most popular dermatology videos on TikTok.Based on the National Ambulatory Medical Care Survey, we generated a list of the top 20 most commonly diagnosed dermatologic conditions. 4 On September 18, 2020, these diagnoses were queried as hashtags on TikTok, and the 8 diagnoses with the most videos were evaluated (Table I). The top 25 videos per diagnosis were identified based on engagement, a TikTok metric based on views, likes, comments, and shares. Videos unrelated to dermatology, paid advertisements, and non-English videos were excluded. Two investigators classified the remaining videos into $1 categories based on content. Interrater reliability was calculated using Cohen . Educational videos were subcategorized and compared with American Academy of Dermatology (AAD) guidelines to determine reliability. 5 Four board-certified dermatologists reviewed content assessment. The identities of content creators were confirmed through biographic information on TikTok or other linked social media platforms; board-certified dermatologists were confirmed through the AAD. Identity confirmation required $2 sources of congruent biographic information. Statistical analysis was performed using the z score test for 2 population proportions. P \.05 was considered statistically significant.Of the 200 videos identified, 171 were included. These videos amassed [521 million views. Videos were most often related to patient experiences/ testimonies, followed by education, clinical demonstrations/live procedures, and product reviews/nonpaid advertisements (Table I). Cohen yielded 0.988, showing excellent interrater reliability on content categorization. Content creators were most commonly patients (48.0%), board-certified dermatologists (25.8%), and estheticians (4.8%) (Table I). Board-certified dermatologists were the main source of educational videos (41.3%), adhering to AAD guidelines 96.8% of the time (Table II).Percentages are based on 171 total videos. *Videos were classified into $1 categories. y Defined as information about prevention, cause, diagnosis, and treatment of skin disease. z Defined as advice on skin appearance, and use/application of beauty and skin care products.x Makeup artists, barbers, relatives of patients, and unidentified posters.

No abstract