By helping to promote the future integration of genetic testing in health care delivery, including clinical decision making, the MVP is designed to contribute to the development of precision medicine.

The American Academy of Pediatrics (AAP) has recommended that children younger than 24 months of age not be exposed to television. Nevertheless, television programs and home videos are increasingly produced for very young children. This article reviews the extant research concerning television and very young children with respect to the AAP recommendation. More very young children are currently watching television than in the recent past; they pay substantial attention to TV programs and videos made for them. When learning from videos is assessed in comparison to equivalent live presentations, there is usually substantially less learning from videos. Although one study finds positive associations of language learning with exposure to some children’s TV programs, other studies find negative associations of viewing with language, cognitive, and attentional development. Background TV is also a disruptive influence. Evidence thus far indicates that the AAP recommendation is well taken, although considerably more research is needed.

Rheumatoid arthritis is a systemic autoimmune disease characterized by excess morbidity and mortality from cardiovascular disease. Mechanisms linking rheumatoid arthritis and cardiovascular disease include shared inflammatory mediators, post-translational modifications of peptides/proteins and subsequent immune responses, alterations in the composition and function of lipoproteins, increased oxidative stress, and endothelial dysfunction. Despite a growing understanding of these mechanisms and their complex interplay with conventional cardiovascular risk factors, optimal approaches of risk stratification, prevention, and treatment in the context of rheumatoid arthritis remain unknown. A multifaceted approach to reduce the burden posed by cardiovascular disease requires optimal management of traditional risk factors in addition to those intrinsic to rheumatoid arthritis such as increased disease activity. Treatments for rheumatoid arthritis seem to exert differential effects on cardiovascular risk as well as the mechanisms linking these conditions. More research is needed to establish whether preferential rheumatoid arthritis therapies exist in terms of prevention of cardiovascular disease. Ultimately, understanding the unique mechanisms for cardiovascular disease in rheumatoid arthritis will aid in risk stratification and the identification of novel targets for meaningful reduction of cardiovascular risk in this patient population.

This study investigated the hypothesis that background television affects interactions between parents and very young children. Fifty‐one 12‐, 24‐, and 36‐month‐old children, each accompanied by 1 parent, were observed for 1 hr of free play in a laboratory space resembling a family room. For half of the hour, an adult‐directed television program played in the background on a monaural television set. During the other half hour, the television was not on. Both the quantity and quality of parent–child interaction decreased in the presence of background television. These findings suggest one way in which early, chronic exposure to television may have a negative impact on development.

No abstract

Accurate information on behavior of young children at home is crucial to the study of child development. The present study compared parent diaries of 5-year-old children's time spent with television to concurrent automated time-lapse video observations. In addition, a number of control groups were employed to assess the effects of observational equipment in the homes. The sample consisted of 334 mostly white middle-class families, of whom 106 had observational equipment installed. Results indicated no systematic subject selection of families who were willing to have observational equipment as compared to the controls. In addition, there were no differences in reported viewing behavior between the observed families and controls. Of 3 types of parent estimates of 5-year-old TV viewing, concurrent diaries correlated best with video observation (r = .84) and produced a very small absolute mean time error. Direct parent estimates of typical time spent viewing produced smaller correlations and large overestimates as compared with diaries.

This experiment tests the hypothesis that background, adult television is a disruptive influence on very young children's behavior. Fifty 12-, 24-, and 36-month-olds played with a variety of toys for 1 hr. For half of the hour, a game show played in the background on a monaural TV set. During the other half hour, the TV was off. The children looked at the TV for only a few seconds at a time and less than once per minute. Nevertheless, background TV significantly reduced toy play episode length as well as focused attention during play. Thus, background television disrupts very young children's play behavior even when they pay little overt attention to it. These findings have implications for subsequent cognitive development.

No abstract