Kahoot! is a popular game-based learning platform. This study aims to investigate whether there is a relationship between Kahoot! score and student’s grade in the traditional examination (GTE), and to understand their perception about the use of this platform. A cross-sectional study was developed in the Human Anatomy course, which is divided into 5 topics of systemic anatomy (TSA). 5-question quizzes about the taught subject were given at the end of 66.7% of the lectures. 53 students who participated in at least one of the quizzes were included. In each TSA, students were subjected to a traditional examination (GTE, scale 0-10) and the mean of Kahoot! scores (MKS, scale 0-6000) was calculated, totalizing 190 independent observations. An opinion questionnaire was given at the course’s end. Spearman’s test analyzed the correlation between MKS and GTE; area under the ROC curve (AUC) evaluated MKS’s ability to predict GTE; chi-square test verified the association between the categorical variables. There was a positive moderate correlation between MKS and GTE (rho=0.43, p<0.001). MKS performed regularly to predict GTE≥9 (AUC=0.734). 67.8% of the students in the MKS≥3000 group obtained GTE≥9, versus only 28.0% in the MKS<3000 group (p<0.001). Amongst the <20-year-old students, 83.3% agreed that Kahoot! was important to motivate them as they studied, versus 52.4% in the ≥20-year-old group (p=0.041). Kahoot!’s score can provide immediate feedback about the student’s learning process, and it serves as a parameter to predict their final performance. The motivation to use Kahoot! can be influenced by the students’ age.
With the emergence of Molecular Targeted Therapy, the interest in studying immunogenetic components that act in carcinogenesis has grown. The role of the estrogen receptor (ER) in initiation and progression of breast cancer is well documented and the estrogen treatment may affect expression of proteins described as tumor stem cell biomarkers in estrogen-sensitive breast cancer. The aim of this study is to analyze the expression of CD44 and CD326 on MCF-7 (ER+) and MDA-MB-231 (ER-) cell lines treated with 17β-estradiol for different periods. Our results indicate that 17β-estradiol can modulate CD44 and CD326 expression in breast cancer cells that have functional estrogen receptors in a time dependent manner. To our knowledge, this is the first study to investigate the influence of 17β-estradiol on CD44 and CD326 expression in MCF-7 and MDA-MB-231 cell lines. Further investigations with primary patient samples and their cultures will enhance our knowledge on the effect of hormones on breast cancer.
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