We have developed a neurophysiologic model for objectively understanding temperature-related reversible changes in axonal conduction in multiple sclerosis. Our observations corroborate the hypothesis that changes in core body temperature (heating and cooling) are associated with stereotypic decay and restoration in axonal conduction mechanisms.
patients with MS were APL. This provides a cumulative incidence higher than currently expected (reported incidences between 0.07% 4 and 0.80% 6 when considering only series of more than 100 patients with MS). The complete references of reported cases of t-AL in patients with MS treated with MTZ are provided in the e-references on the Neurology ® Web site at www.neurology.org.Considering the MTZ regimen administrated, there was no relation between the treatment scheme and the occurrence of t-AL. There was no t-AL in the low-dose regimen, which was used in special cases to enable tolerance, but the low number of patients in that regimen does not enable us to draw significant conclusions. Nowadays, the real risk of t-AL is not known, as the total number of patients with MS who have received MTZ is unknown and leukemia cases might be underreported. The results of this prospective observational study stress the necessity of re-evaluating this risk.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.