We disclose a Ni‐catalyzed regioselective dialkylation reaction of alkenylarenes with α‐halocarbonyls and alkylzinc reagents. The reaction produces γ‐arylated alkanecarbonyl compounds with the generation of two new C(sp3)−C(sp3) bonds at the vicinal carbons of alkenes. This reaction is effective for the use of primary, secondary and tertiary α‐halocarboxylic esters, amides and ketones in conjunction with primary and secondary alkylzinc reagents as the sources of two C(sp3) carbons for the dialkylation of terminal and cyclic internal alkenes.
We disclose a Ni-catalyzed regioselective dialkylation reaction of alkenylarenes with -halocarbonyls and alkylzinc reagents. The reaction produces -arylated alkanecarbonyl compounds with the generation of two new C(sp3)-C(sp3) bonds at the vicinal carbons of alkenes. This reaction is effective for the use of primary, secondary and tertiary -halocarboxylic esters, amides and ketones in conjunction with primary and secondary alkylzinc reagents as the sources of two C(sp3) carbons for the dialkylation of terminal and cyclic internal alkenes.
We disclose a Ni‐catalyzed regioselective dialkylation reaction of alkenylarenes with α‐halocarbonyls and alkylzinc reagents. The reaction produces γ‐arylated alkanecarbonyl compounds with the generation of two new C(sp3)−C(sp3) bonds at the vicinal carbons of alkenes. This reaction is effective for the use of primary, secondary and tertiary α‐halocarboxylic esters, amides and ketones in conjunction with primary and secondary alkylzinc reagents as the sources of two C(sp3) carbons for the dialkylation of terminal and cyclic internal alkenes.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.