No abstract

No abstract

No abstract

for the INSITE study team IMPORTANCE Positive margins following breast-conserving surgery (BCS) are often identified on standard pathology evaluation. Intraoperative assessment of the lumpectomy cavity has the potential to reduce residual disease or reexcision rate following standard of care BCS in real time.OBJECTIVE To collect safety and initial efficacy data on the novel pegulicianine fluorescence-guided system (pFGS) when used to identify residual cancer in the tumor bed of female patients undergoing BCS. DESIGN, SETTING, AND PARTICIPANTSThis prospective single-arm open-label study was conducted as a nonrandomized multicenter controlled trial at 16 academic or community breast centers across the US. Female patients 18 years and older with newly diagnosed primary invasive breast cancer or ductal carcinoma in situ DCIS undergoing BCS were included, excluding those with previous breast cancer surgery and a history of dye allergies. Of 283 consecutive eligible patients recruited, 234 received a pegulicianine injection and were included in the safety analysis; of these, 230 were included in the efficacy analysis.

No abstract

No abstract

A fundamental characterization of friction requires an accurate understanding of how the surfaces in contact interact at the nano or atomic scales. In this work, molecular dynamics simulations are used to study friction and deformation in the dry sliding interaction of two hemispherical asperities. The material simulated is copper and the atomic interactions are defined by the embedded atom method potential. The effect of interference, d, relative sliding velocity, v, asperity size, R, lattice orientation, h, and temperature control, on the friction characteristics are investigated. Extensive plastic deformation and material transfer between the asperities were observed. The sliding process was dominated by adhesion and resulted in high effective friction coefficient values. The friction force and the effective friction coefficient increased with the interference and asperity size but showed no significant change with an increase in the sliding velocity or with temperature control. The friction characteristics varied strongly with the lattice orientation and an average effective friction coefficient was calculated that compared quantitatively with existing measurements.

No abstract