Fish oils rich in n-3 fatty acids have been shown to decrease plasma lipid levels, but the underlying mechanism has not yet been elucidated. This investigation was performed in order to further clarify the effects of purified ethyl esters of eicosapentaenoic acid (EPA-EE) and docosahexaenoic acid (DHA-EE) on lipid metabolism in rats. The animals were fed EPA-EE, DHA-EE, palmitic acid, or corn oil (1 g/kg/d) by orogastric intubation along with a chow background diet for three months. At the end the animals were sacrificed. Plasma and liver lipids were measured, as well as lipid-related enzyme activities and mRNA levels. The fatty acid composition of plasma and different tissues was also determined. This study shows that, compared to the corn oil control, EPA-EE and DHA-EE lowered plasma cholesterol level, whereas only EPA-EE lowered the amount of plasma triacylglycerol. In liver peroxisomes, both EE preparations increased fatty acyl-CoA oxidase FAO activities, and neither altered 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase activities. In liver microsomes, EPA-EE raised HMG-CoA reductase and acyl-CoAicholesterol acyltransferase activities, whereas DHA-EE lowered the former and did not affect the latter. Neither product altered mRNA levels for HMG-CoA reductase, low density lipoprotein-receptor, or low density lipoprotein-receptor related protein. EPA-EE lowered plasma triacylglycerol, reflecting lowered very low density lipoprotein secretion, thus the cholesterol lowering effect in EPA-EE-treated rats may be secondary to the hypotriacylglycerolemic effect. An inhibition of HMG-CoA reductase activity in DHA-EE treated rats may contribute to the hypocholesterolemic effect. The present study reports that 20:5n-3, and not 22:6n-3, is the fatty acid primarily responsible for the triacylglycerol lowering effect of fish oil. Finally, 20:5n-3 was not converted to 22:6n-3, whereas retroconversion of 22:6n-3 to 20:5n-3 was observed.

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Metagraywackes and metapelites from the Paleoproterozoic Birimian Supergroup in the Birim diamondiferous field, southern Ghana, were analyzed for their major and trace element contents. Compared to early Proterozoic crust, the metasedimentary rocks are enriched in ferromagnesian elements but depleted in rare earth elements (REE), high field strength elements (HFSE) (with exception of Zr), and Th. They show REE patterns similar to their Archean counterparts. The chemical data indicate that the sediments were derived from a local source of mixed felsic-mafic composition, with the latter dominating. The source rocks were the basaltic to dacitic volcanic rocks and granitoids within the Birimian greenstone belts. The chemical data further suggest their deposition in a tectonic setting comparable to modern island arcs, and that minimal old upper crust (i.e., pre-Birimian sources) was involved in their formation. The analyzed metasedimentary rocks have Eu-anomalies and Gd N /Yb N , Sm/Nd, Th/Sc, Cr/Sc and Cr/Th ratios that closely resemble those of their Archean counterparts, and therefore inconsistent with models suggesting abrupt compositional changes in upper crust at the Archean-Proterozoic boundary.

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A geochemical study was carried out on Lower Cretaceous sedimentary rocks of the Wakino Subgroup, Kenseki Formation, and Sasayama Group, distributed in the Inner Zone of Southwest Japan. The chemical characteristics of the Lower Cretaceous sediments indicate that these rocks are immature firstorder sediments derived from igneous and/or meta-igneous rocks of predominantly felsic composition. The sediments from the Kenseki Formation and the Sasayama Group, however, show high Cr and Ni abundances, suggesting a significant contribution of detritus from ultramafic rocks. Weathering at the source areas was moderate.The high Th/U ratios (mostly > 3.8), negative Eu anomalies (Eu/Eu* between 0.67 and 0.93) and Th/Sc ratios (mostly between 0.5 and 1) of the Lower Cretaceous sediments suggest their derivation dominantly from an old upper crust with minor amounts of young arc-derived detritus. The major, trace and rare earth element compositions imply that deposition took place in an active continental margin environment. The small amounts of young arc-derived material in the sediments support the inference by other workers that arc magmatism was not so prominent in Southwest Japan during the early Cretaceous.

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Sandstones from the Upper Cretaceous to Eocene succession of Central Palawan are rich in quartz grains and acidic volcanic rock fragments. Potassium feldspar grains and granitic rock fragments are commonly observed. The moderate to high SiO 2 and low FeO plus MgO contents of the sandstones support the proposal that clasts were derived from a continental source region. Southern China (Kwangtung and Fukien regions) is inferred to be the source area of the sandstones. The sedimentary facies of the Upper Cretaceous to Eocene succession consist of turbidite and sandstones, suggesting that they were deposited in the deep sea portions of submarine-fans and basin plains situated along a continental margin. These features indicate that the Upper Cretaceous to Eocene succession of the Central Palawan were derived and drifted from the southern margin of China. The tectonic history related to the formation of Palawan Island is also discussed.

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