Atrial fibrillation can be treated using low voltage (LV) (amplitude of intracardiac electrogram < 0.5mV) targeted ablation. However, catheter characteristics can alter the voltage leading to changes in identified LV areas. This study evaluates the impact electrode size has on the voltage in healthy and diseased tissue. A realistic setup was generated of tissue, bath and two high conductivity electrodes, with centre to centre spacing of 2mm, placed in contact to the tissue and perpendicular to the planar wavefront. Simulations were performed varying the dimensions of the cubic electrodes from 0.2 to 1.6 mm in healthy tissue and including fibrosis in different locations. An inverse relationship was found between the electrode size and the voltage. When including epicardial fibrosis, a voltage decrease of 1 mV was found in electrodes. When fibrosis was placed closer to the electrodes, a morphological signal change was seen and a 9 mV drop in voltage for small electrodes. Large electrodes deliver smaller voltages. A fibrotic area on the epicardial side has a small influence on the voltage, which was not amplified by increasing electrode size. Endocardial fibrosis delivers significantly smaller voltages than healthy tissue. Little difference in the voltage was seen between large electrodes (>1 mm) in diseased tissue. Electrode size needs to be accounted for when determining LV areas using different catheters.
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