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Background. From the first reports of the linguist Noam Chomsky it has become clear that the development of language has an important genetic component. Several reports in families have shown the relationship between language disorders and genetic polymorphisms. The FOXP2 gene has been a fundamental piece for the understanding of language development. This gene codes for a transcription factor containing a forkhead domain of DNA binding and participates in the regulation of the expression of a large number of genes involved in the embryonic development of fundamental neuronal structures needed for the development of speech and language. Objective. To present an updated view of the relationship between FOXP2 and language alterations in psychiatric pathology. Method. Narrative review of information reported in databases on the recent advances supporting genetic participation in language disorders of psychiatric illness. Results. Update of content related to FOXP2 and its participation in language alterations in psychiatric diseases. Discussion and conclusion. Advances in the genetic study of language disorders in psychiatric pathology open up new avenues of investigation that allow us to explore how language emerged and how it evolved, as well as to carry out comparative studies on the structure and functioning of genes to approach the understanding of this complex characteristic that makes us human.

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Introducción: La epilepsia representa una de las principales causas de morbilidad en neuropediatría. El inicio temprano de las crisis epilépticas, se relaciona con menor desempeño intelectual a largo plazo, y alteraciones en las habilidades adaptativas. Objetivo: Aplicar escala de evaluación pediátrica del inventario de discapacidad-prueba adaptativa por computadora (PEDI-CAT) en pacientes pediátricos con epilepsia. Métodos: Se realizó un estudio de nivel descriptivo, tipo observacional, prospectivo, trasversal y analítico, realizado el Departamento de Neurología Pediátrica del Hospital Infantil de México Federico Gómez, en la Ciudad de México. El reclutamiento de los pacientes fue durante abril y diciembre de 2020. Resultados:  los pacientes con epilepsia presentaron un percentil <5 en sus habilidades de movilidad 22 (35,4%), actividades diarias 19(30,6%), social-cognitivas 19(30,6%), lo que significa que están por debajo de rango normal comparado con niños de su edad. Conclusiones:  los pacientes con epilepsia presentaron un percentil <5 en el dominio de actividades diarias, movilidad y social-cognitiva, lo que significa que están por debajo de rango normal comparado con niños de su edad. Por tanto, la epilepsia debe ser considerado un trastorno que afecta la capacidad adaptativa de los pacientes y no sólo una patología cuya manifestación son las crisis, su detección temprano con el uso de escalas como PEDI-CAT se traduce en la identificación y planificación de estrategias terapéuticas eficaces para mejorar calidad de vida de los pacientes Palabras Clave: Epilepsia, Conducta Adaptativa, Trastornos del Neurodesarrollo.   ABSTRACT Introduction: Epilepsy represents one of the main causes of morbidity in pediatric neurology. The early onset of epileptic seizures is related to lower long-term intellectual performance, and alterations in adaptive skills. Objective: To apply the Pediatric Evaluation of Disability Inventory Computer Adaptive Test (PEDI-CAT) report in pediatric patients with epilepsy. Methods: A descriptive, observational, prospective, cross-sectional and analytical study was carried out in the Department of Pediatric Neurology at Hospital Infantil de México Federico Gómez, in Mexico City. Patient recruitment took place between April and December 2020. Results: patients with epilepsy presented a <5 percentile in their mobility skills 22 (35.4%), daily activities19 (30.6%), social-cognitive 19 (30.6%), which means that they are below of normal range compared to children his age. Conclusions: patients with epilepsy presented a <5 percentile in the domain of daily activities, mobility and social-cognitive, which means that they are below the normal range compared to children of their age. Therefore, epilepsy should be considered a disorder that affects the adaptive capacity of patients and not just a pathology whose manifestation is seizures, its early detection with the use of scales such as PEDI-CAT translates into the identification and planning of strategies effective therapeutics to improve the quality of life of patients Keywords: Epilepsy, Adaptation, Psychological, Neurodevelopmental Disorders.