This study aimed to evaluate the efficiency of aqueous extraction to obtain bioactive phytochemicals from grains and residual husk of organic Arabic coffee, as well as to develop a beverage with high antioxidant capacity and assess its sensorial acceptability. Aqueous extracts were obtained from dried and crushed coffee beans and husk. Various extraction methods were used to select the one capable of extracting the most amount of total phenolic constituents. The decoction without mechanical agitation was highlighted as the best method, from which the chemical characterization, antioxidant capacity and the presence of antinutrients were investigated. Three beverage formulations were prepared with coffee husk extract and added in different proportions to concentrated pineapple juice. The beverages were analyzed for antioxidant capacity, microbiological properties and sensorial acceptance. No hemagglutinins and low oxalate content were found in the samples. The antioxidant capacity of the aqueous husk extract was higher than that of the grains. The beverage made with the addition of concentrated pineapple juice was sensorially preferred by the tasters. On addition, it contributed to raise the antioxidant capacity of the beverage. Ot was concluded that the aqueous extract of coffee husk appears as a new alternative for the beverage industry.

Chitosan films entrapped with the Mansoa hirsuta fraction (CMHF) was developed as a new dressing for wound care. The chromatographic profile of the M. hirsuta fraction (MHF) was evaluated by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry, and the results showed that MHF is rich in acid triterpenes. Physicochemical characterization of the films prepared using the solvent casting method was performed by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetry (TGA), differential scanning calorimetry (DCS), scanning electron microscopy (SEM), atomic force microscopy (AFM), and mechanical properties. CMHF exhibited characteristic bands of both chitosan and MHF, revealing a physical mixture of both. CMHF presented an amorphous nature, thermostability, and dispersion of MHF in the chitosan matrix, resulting in a rough structure. Incorporation of M. hirsuta fraction into chitosan matrix favorably enhanced the mechanical performance and films thickness. The in vivo wound treatment with CMHF for seven days showed a characteristic area of advanced healing, re-epithelization, cell proliferation, and collagen formation. Furthermore, wound closure reached 100% contraction after 10 days of treatment with modulation of interleukins. The incorporation of M. hirsuta fraction into chitosan films was advantageous and showed great potential for stimulating wound repair and regeneration.

This interdisciplinary analogue 3D Memory Game is a version of a card-based memory game, developed to encourage high school students to use deductive reasoning skills and to understand reflection (mirror images), symmetry, and chirality. Instead of cards, three-dimensional pieces are used in order to facilitate the understanding of the spatial arrangement of things, both geometric objects and organic compounds. Correlating geometric objects with the simple molecular model representation of organic compounds, the game promotes knowledge transposition to spatial recognition of chemical structures and chirality in formal education, classrooms, or nonformal educational settings (e.g., a science center or discovery center or university outreach setting). The game was used in 2016 in a classroom with 16 students in a high school in São Gonçalo, Rio de Janeiro, Brazil, as well as at a science fair in 2015. The game lasts 15–25 min when played by 5 or 3 groups of 2 students, respectively. On the basis of the feedback of students and teachers, the game was considered interesting, and the students were motivated to participate more actively in the classroom. Learning about these concepts by the students was significant.

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Coffee is a very popular drink, which is traditionally used to supplement meals and for hedonistic purposes beyond of its functional and health properties. The coffee provides a multitude of bioactive by -products that can be used for the formulation of dermocosmetics. In this context, this work aimed to develop an emulsion using extracts of Coffea arabica as well as evaluate its physicochemical stability and antioxidant activity. Two formulations were developed with incorporation of different fractions of green seeds from Coffea arabica. Then, both formulations were submitted to extremes temperatures (5 and 45 o C) for 15 days, and pH, electrical conductivity, organoleptic characteristics and presence of viable microorganisms were determined. Total phenolic content was estimated by Folin-Ciocalteu method. Afterwards, fractions and cream were tested by 2,2diphenyl-1-picrylhydrazyl (  DPPH) radical scavenging assay. The formulation 2 showed no instability for all parameters evaluated. The hexane, glycolic, methanol, chloroform and ethyl acetate fractions, and cream at 150 µg/mL deactivated 