Background: Geographic stomatitis is an uncommon oral lesion that presents similar clinical, histopathological and genetic features as those of psoriasis. These findings suggest that this lesion may actually represent an oral manifestation of psoriasis. We report one case of geographic stomatitis and discuss a possible connection between this condition and psoriasis.Main observations: A 37-year-old woman presented with red patches, surrounded by a white border on the labial mucosa and a positive family history of psoriasis. Histopathological examination, immunohistochemical analysis with antibodies against CD4, CD8, CD20, CD68, CD31, and Ki-67 and HLA-A*, -B*, -C*, -DRB1*, -DQA1* and -DQB1* genotyping were performed. Histopathological examination revealed parakeratosis, marked elongation of rete ridges with acanthosis and clubbing, exocytosis, Munro microabscesses, pustule of Kogoj, dilated tortuous vessels at the tip of dermal papillae, and predominant superficial and perivascular lymphocytic chronic inflammatory cell infiltrate. Immunohistochemistry analysis revealed a predominant T-cell subepithelial infiltrate. Based on the referred clinicopathological findings and in the absence of cutaneous lesions, the diagnosis of geographic stomatitis was confirmed. Conclusions:This case and theoretical data indicate that geographic stomatitis may be an oral manifestation of psoriasis. Moreover, to improve our understanding, psoriatic patients should routinely undergo a detailed oral examination and patients with geographic stomatitis should routinely be submitted to a cutaneous routine examination. (J Dermatol Case Rep.

No abstract

The increase in age-adjusted incidence rate for tongue cancers (except for other and unspecified parts of the tongue in men), with most patients over 50 years of age, with low education levels, and advanced disease reinforces the need for interventions that address access to health promotion resources and medical care in Brazil.

Mucosal melanomas are primary malignant neoplasias originated from melanocytes within mucous membranes in any part of mucosal surface lining, more commonly, in the nasal cavity and accessory sinuses, oral cavity, lips, pharynx, vulvar, vaginal, cervix and anorectal mucosa. Epidemiology data regarding mucosal melanomas in Brazil is scarce, hence the motivation to conduct this research paper. The χ2 test was used to compare categorical variables. Forward stepwise logistic regression method was used in the multivariate analysis to identify independent predictors of early death. A total of 801 patients were included in the analysis. Surgical resection is frequently the first approach to primary tumours (65.3%), even though the utility of lymph node surgery and radiation therapy is not well established. Advanced stage was observed in more than two thirds of patients. Early death was observed in 28.3%. MM cases with regional or distant metastases as well as those located in unusual locations had almost 4 times more risk for early death. Besides that, MM located in lips, oral cavity and pharynx and those receiving chemotherapy had 2 times more risk of early death.Mucosal melanoma (MM) is a primary malignant neoplasia originated from melanocytes within mucous membranes in any part of mucosal surface lining, more commonly, the head and neck region, followed by anorectal mucosa and vulvovaginal mucosa 1-3 . MM is rare and represents approximately 1% of all melanoma cases 1 . On top of that, the disease has a terrible prognosis, with a five year survival rate of only 25% compared to 80% in cutaneous melanomas 1,2 .Feller and collaborators state that regardless of the treatment approach, MM is constantly fatal 4 . Notwithstanding, Ascierto and collaborators believe that the advances in melanoma treatment, especially related to the new discoveries on the scope of the molecular profile of these tumours, boosted the optimism when it comes to the possibility of more effective systemic therapies available 5 .There is a lack of nationwide studies regarding MMs in Brazil. The purpose of this research was to fill this gap clarifying the scientific community about the epidemiological characteristics of MM in the country with special emphasis on MM's early death predictors. open Scientific RepoRtS | (2020) 10:505 | https://doi.org/10.1038/s41598-019-57253-6www.nature.com/scientificreports www.nature.com/scientificreports/ penis and other male urinary tract non-specified MM, genitourinary tract, peritoneum and retroperitoneum MM. Regarding the status of patients at the end of first course of treatment, progressive disease, relapsed disease or death were the highest (68.9%) in anorectal MM and partial remission, stable disease and complete response reached 63.0% in nasal and paranasal MM ( Table 3).The univariate analysis of the risk factors for early death in mucosal melanoma is presented in Table 4, while the multivariate analysis is presented in Table 5. MM cases with regional or distant metastases as well as those located in the dig...

Considering the malignant neoplasms observed in the oral cavity, squamous cell carcinoma (SCC) is the most diagnosed histological type. In 2018, 354,864 new cases of oral cancer were estimated worldwide, with an average of 70% in male patients. In the same year, the number of deaths was 177,384, of which 119,693 occurred in males and 57,691 in females (Bray et al., 2018).According to the National Cancer Institute of Brazil (INCA), considering the oral cavity as the primary location, 11,180 cases in men and 4,010 in women were estimated for 2021 in Brazil. In 2018, there were 1,975 cases of deaths from SCC in the tongue region, 77% of which were in males. In the southeastern region of Brazil, except for non-melanoma skin tumors, cancer of the oral cavity is the fifth most common in men and the 13th in women (INCA, 2019).