Heteroaryl sulfonamides are important structural motifs in the medicinal and agrochemical industries. However, their synthesis often relies on the use of heteroaryl sulfonyl chlorides, which are unstable and toxic reagents....
The enantioselective addition of isoxazolidin-5-ones to the β-carbon of allenoates has been carried by using a novel spirobiindane-based quaternary ammonium salt catalyst. This protocol, which proceeds under classical liquid-solid phase-transfer conditions, gives access to highly functionalized β2,2-amino acid derivatives with good enantioselectivities and in high yields.
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