Very small numbers of resident T-lymphocytes are present in the dermis of normal skin of humans, cattle, sheep, dogs, and alpacas. The objective of this study was to determine the prevalence of lymphocytes, CD3+ cells (T-lymphocyte), and Pax5+ cells (B-lymphocyte) in the dermis of normal cat skin. Skin-biopsy specimens from the normal skin of the dorsolateral thorax from 29 cats were examined immunohistochemically for the presence of CD3+ and Pax5+ cells in the superficial and deep dermis. Two CD3+ lymphocytes were found in the superficial dermis in 1 of 29 cats. B-lymphocytes were not found.
The objective of this study was to characterize the histological appearance, prevalence, and association of pilosebaceous dysplasia (PD) in dogs with yeast dermatitis. A retrospective, light-microscopic study of H&E-stained skin-biopsy specimens from 670 dogs with non-neoplastic dermatoses and 28 normal dogs was performed. Chi-square and rank-sum analyses were used to compare the prevalence and abundance of PD in dogs with yeast dermatitis, normal dogs, and dogs with non-yeast dermatoses. PD was observed in 76 of 98 (78%; 95%confidence interval (CI) 68%, 85%) of dogs with yeast dermatitis and in 14 of 572 (2.4%; CI 1.4%, 4.2%) dogs with non-yeast dermatoses. PD was not observed in any normal dogs (CI 0%, 15%). The prevalence (presence, yes/no) of PD was significantly greater in dogs with yeast dermatitis (chi-square = 424.49; degrees of freedom = 2; p<0.0001) than in dogs with non-yeast dermatoses and in normal dogs. Also, among the dogs with PD present, the percentage of affected units in each dog was greater (p=0.0002) in dogs with yeast dermatitis (minimum 12%; median75%; maximum 100% affected units/dog) than in dogs with nonyeast dermatoses (minimum 3%; median 30%; maximum 100%). There was no significant difference (p>0.05) between the prevalence of PD in dogs with non-yeast dermatoses and in normal dogs. These findings suggest that the finding of PD in skin-biopsy specimens of dogs is significantly associated with yeast dermatitis and could be considered when making this histological diagnosis.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.