The components of the claustrum have been identified by gene expression in mice, but there is still uncertainty about the location of homologous components in primates. To aid interpretation of homologous elements between rodents and primates, we used a current understanding of pallial topology, species-specific telencephalic deformation, and gene expression data. In both rodents and primates, pallial areas maintain conserved topological relationships regardless of relative differences in pallial expansion. The components of the claustrum in primates can, therefore, be identified on the basis of their conserved topological relationships and patterns of gene expression. In rodents, a fairly straight telencephalic long axis runs between the early septopreoptic and amygdalar poles of the pallium. In primates, however, the remarkable dorsal pallial expansion causes this axis to be distorted to form a C shape. This has resulted in a number of errors in the interpretation of the location of claustral components. These errors are likely to have resulted from the unexpected topographical positioning of claustral components due to the bent telencephalic axis. We argue that, once the telencephalic distortion has been accounted for, both rodents and primates have homologous claustral components, and that the topological relationships of these components are conserved regardless of differences in the relative expansion of pallial areas.

It is widely assumed that the hippocampal formation seen in laboratory rodents and in primates is typical of that seen in other mammals. We have tested this assumption by examining sections of brains of 56 mammals from 20 mammalian orders from images on the http://brainmuseum.org website. We found wide variation in the form of the hippocampal formation, the most extreme examples of which are seen in ungulates, which possess an unusual elongation of the distal CA1 of the septal hippocampus. This phenomenon has not previously been reported. In individual coronal sections of the brains of seven artiodactyl ungulates, the pyramidal layer of CA1 is four times as long as CA2 + CA3. In a perissodactyl ungulate (Burchell's zebra) the distal end of CA1 is so large that it forms a number of folds. A similar but less pronounced CA1 elongation was seen in the brains of 14 carnivores. A modest elongation of CA1 is also present in some other placental mammals, notably the elephant shrew, hyrax, capybara, beaver, and rabbit. The elongation was not present in brains of primates, marsupials, or monotremes. The distal part of CA1 has been shown to play a role in object integration into the spatial map. We hypothesize that the distal CA1 enlargement could serve to enhance the ability to integrate objects into spatial navigation, which would be an advantage for migrating herds of ungulates. We suggest that the remarkable elongation of Q5 CA1 represents a major evolutionary specialization in the ungulates.

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