Flotillin 2 (flot-2) is a highly conserved protein isolated from caveolae/ lipid raft domains that tether growth factor receptors linked to signal transduction pathways. Flot-2 protein and mRNA were increased in tumorigenic and metastatic melanoma cell lines in vitro, and the immunostaining intensity increased substantially across a tissue array of melanocytic lesions.

In this review of megaloblastic anemia (MA), an overview of vitamin B 12 and folate body requirements, biochemical pathways, and laboratory testing strategies will be provided. However, the focus of this review is the classic and unique features of MA in blood and bone marrow. Acquired MA is a benign disorder for many, but can be detrimental for some. The clinical presentation can vary considerably, and the spectrum of symptoms and signs is diverse and quite broad. Prompt recognition and therapy are critical to prevent potential irreversible damage and clinical sequelae, especially in patients with vitamin B 12 deficiency. A delay in diagnosis of vitamin B 12 deficiency can result in significant neurologic sequelae that may not fully resolve with treatment, including in neonates and young infants. The blood and bone marrow features in MA can closely mimic thrombocytopenic purpura, myelodysplasia, and other myeloid neoplasms. Both pancytopenia and normal MCV at presentation are common in MA and raise unique challenges for the diagnostician. Partially treated MA is also a significant diagnostic "trap". MA is highly responsive to treatment, and patients tend to improve rapidly upon treatment initiation. However, the broad range of clinical and hematologic features makes the rapid, successful diagnosis of MA a unique challenge for the hematopathologist. Even in the era of state-of-the-art laboratory testing, a high suspicion is required.

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Background: Road traffic accidents (RTA) are the leading cause of unnatural deaths in the world and a major burden on the world’s economy. The aim was to study the prevalence of road traffic accident among children.Methods: It is a retrospective cross sectional study. Data collected from the hospital records in PICU. Children studied are either admitted directly for road traffic accident or referred to our centre for complicated injuries. children of 1 to 18 years are studied, details of address, locality (either rural, urban) road safety precautions used, mode of injury, type of vehicle, type of injury, number of passengers, complications, outcome of injury are collected and entered in prescribed proforma, and impact of each one is analysed and magnitude is studied. Study period was from June 2014 to June 2016.Results: This study shows that road traffic accident prevalence is more in 15-18 year age group (31%), and males are affected more commonly (79.5%), among these majority of children were from rural area (73%), more common type of injury were complicated injuries (85.1%). Children travelling in 2 wheelers were affected more (74.9%). Results analysed with age of victims and type of injury, p value <0.05 is considered significant.Conclusions: To bring the mortality rate down, children especially with rural background should be made aware about the importance of strict compliance to traffic rules and regulations. Government need to start implementing traffic rules awareness programme among rural people.