Chronically instrumented dogs underwent 2- or 5-h regional reductions in coronary flow that were followed, respectively, by balanced reductions in myocardial contraction and O(2) consumption ("hibernation") and persistently reduced contraction despite normal myocardial O(2) consumption ("stunning"). Previously unidentified myofibrillar disruption developed during flow reduction in both experimental models and persisted throughout the duration of reperfusion (2-24 h). Aberrant perinuclear aggregates that resembled thick filaments and stained positively with a monoclonal myosin antibody were present in 34 +/- 3.8% (SE) and 68 +/- 5.9% of "hibernating" and "stunned" subendocardial myocytes in areas subjected to flow reduction and in 16 +/- 2.5% and 44 +/- 7.4% of subendocardial myocytes in remote areas of the same ventricles. Areas of myofibrillar disruption also showed glycogen accretion and unusual heterochromatin clumping adjacent to the inner nuclear envelope. The degrees of flow reduction employed were sufficient to reduce regional myofibrillar creatine kinase activity by 25-35%, but troponin I degradation was not evident. The observed changes may reflect an early, possibly reversible, phase of the myofibrillar loss characteristic of hypocontractile myocardium in patients undergoing revascularization.
Incorporating students longitudinally into primary care clinics is highly rated by students. The ECMH model led to improved continuity, improved perceptions of the learning climate, and higher patient centeredness. Preliminary data suggest that students add value and improve patient outcomes during longitudinal clinical experiences.
The purpose of this study was to determine the validity and reliability of a new method for measuring three-dimensional (3D) putting stroke kinematics using the TOMI device. A putting robot and a high-speed camera were used to simultaneously collect data for the validity evaluation. The TOMI device, when used in conjunction with standard 3D coordinate data processing techniques, was found to be a valid and reliable method for measuring face angle, stroke path, putter speed, and impact spot at the moment of ball contact. The validity of the TOMI(R) measurement system was quantified using the 95% limits of agreement method for each aforementioned variable. The practical significance of each validity score was assessed by incorporating the maximum estimated measurement error into the stroke of the putting robot for 10 consecutive putts. All putts were executed from a distance of 4 m on a straight and flat synthetic putting surface. Since all putts were holed successfully, the measurement error for each variable was deemed to be negligible for the purposes of measuring putting stroke kinematics. The influence of key kinematic errors, at impact, on the outcome of a putt was also determined.
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