GRADE (Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study) is a 36-center unmasked, parallel treatment group, randomized controlled trial evaluating four diabetes medications added to metformin in people with type 2 diabetes (T2DM). We report baseline characteristics and compare GRADE participants to a National Health and Nutrition Examination Survey (NHANES) cohort. RESEARCH DESIGN AND METHODS Participants were age ‡30 years at the time of diagnosis, with duration of T2DM <10 years, HbA 1c 6.8-8.5% (51-69 mmol/mol), prescribed metformin monotherapy, and randomized to glimepiride, sitagliptin, liraglutide, or insulin glargine. RESULTS At baseline, GRADE's 5,047 randomized participants were 57.2 6 10.0 years of age, 63.6% male, with racial/ethnic breakdown of 65.7% white, 19.8% African American, 3.6% Asian, 2.7% Native American, 7.6% other or unknown, and 18.4% Hispanic/ Latino. Duration of diabetes was 4.2 6 2.8 years, with mean HbA 1c of 7.5 6 0.5% (58 6 5.3 mmol/mol), BMI of 34.3 6 6.8 kg/m 2 , and metformin dose of 1,944 6 204 mg/day. Among the cohort, 67% reported a history of hypertension, 72% a history of hyperlipidemia, and 6.5% a history of heart attack or stroke. Applying GRADE inclusion criteria to NHANES indicates enrollment of a representative cohort with T2DM on metformin monotherapy (NHANES cohort average age, 57.9 years; mean HbA 1c , 7.4% [57 mmol/mol]; BMI, 33.2 kg/m 2 ; duration, 4.2 6 2.5 years; and 7.2% with a history of cardiovascular disease). CONCLUSIONS The GRADE cohort represents patients with T2DM treated with metformin requiring a second diabetes medication. GRADE will inform decisions about the clinical effectiveness of the addition of four classes of diabetes medications to metformin. The optimal medication management of hyperglycemia in type 2 diabetes (T2DM) is not established. In addition to lifestyle intervention, metformin is the recommended initial medication in T2DM due to its glycemic effectiveness, lack of associated hypoglycemia or weight gain, low cost, and evidence of long-term benefit and safety
In the present work we analyse N = (2, 2) supersymmetric Yang-Mills (SYM) theory with gauge group SU (2) in two dimensions by means of lattice simulations. The theory arises as dimensional reduction of N = 1 SYM theory in four dimensions. As in other gauge theories with extended supersymmetry, the classical scalar potential has flat directions which may destabilize numerical simulations. In addition, the fermion determinant need not be positive and this sign-problem may cause further problems in a stochastic treatment. We demonstrate that N = (2, 2) super Yang-Mills theory has actually no sign problem and that the flat directions are lifted and thus stabilized by quantum corrections. Only the bare mass of the scalars experience a finite additive renormalization in this finite theory. On various lattices with different lattice constants we determine the scalar masses and hopping parameters for which the supersymmetry violating terms are minimal. By studying four Ward identities and by monitoring the π-mass we show that supersymmetry is indeed restored in the continuum limit. In the second part we calculate the masses of the low-lying bound states. We find that in the infinite-volume and supersymmetric continuum limit the Veneziano-Yankielowicz super-multiplet becomes massless and the Farrar-Gabadadze-Schwetz super-multiplet decouples from the theory. In addition, we estimate the masses of the excited mesons in the Veneziano-Yankielowicz multiplet. We observe that the gluino-glueballs have comparable masses to the excited mesons.
Quarks in the adjoint representation have been a subject of study for both conceptual and practical purposes. Conceptually, their differences when it comes to confining and chiral symmetry properties has long been suspected to hold important information on the relation of these two distinguished properties of QCD-like gauge theories. Practically, they have been studied as both a possibility to access finite density quark systems as well as candidate theories for technicolor in beyond-the-standard-model settings. The most elementary object describing such particles is their propagator, though it being gaugedependent. Its properties in the minimal Landau gauge are investigated here both in the quenched and unquenched case for a range of lattice parameters using the Wilson formulation for the gauge group SU(2). It is found that the propagator shows pronounced differences to the case of fundamental quarks, especially towards the chiral limit.
Albeit the standard model is the most successful model of particles physics, it still has some theoretical shortcomings, for instance the hierarchy problem, the absence of dark matter, etc. Supersymmetric extensions of the standard model could be a possible solution to these problems.One of the building blocks of these supersymmetric models are supersymmetric gauge theories. It is expected that they exhibit interesting features like confinement, chiral symmetry breaking, magnetic monopoles and the like. We present new results on N=2 Super Yang Mills theory in two dimensions. The lattice action is derived by a dimensional reduction of the N=1 Super Yang Mills theory in four dimensions. By preserving the R symmetry of the four dimensional model we can exploit Ward identities to fine tune our parameters of the model to obtain the chiral and supersymmetric continuum limit. This allows us to calculate the mass spectrum at the physical point and compare these results with effective field theories. 34th annual International Symposium on Lattice Field Theory
Supersymmetry is one of the possible scenarios for physics beyond the standard model. The building blocks of this scenario are supersymmetric gauge theories. In our work we study the N = 1 Super-Yang-Mills (SYM) theory with gauge group SU(2) dimensionally reduced to two-dimensional N = 2 SYM theory. In our lattice formulation we break supersymmetry and chiral symmetry explicitly while preserving R symmetry. By fine tuning the bar-mass of the fermions in the Lagrangian we construct a supersymmetric continuum theory. To this aim we carefully investigate mass spectra and Ward identities, which both show a clear signal of supersymmetry restoration in the continuum limit.
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