A b s t r a c tIntroduction: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease, with a significant effect on quality of life (QoL). Aim: To evaluate the impact of AD on QoL of Montenegrin infants and their parents and to identify predictors affecting their QoL. Material and methods: The cross-sectional study was conducted between August 2017 and July 2018 and included 186 infants with AD aged 0-4 years and their parents. The severity of disease was measured by the Three-Item Severity (TIS) score, while QoL was assessed with the Infants' Dermatitis Quality of Life Index (IDQOL) and the Dermatitis Family Impact (DFI) questionnaire. Results: The mean overall scores were 14.72 for IDQOL and 17.78 for DFI. The positive correlation was observed between AD severity and both the IDQOL and DFI scores (r = 0.61, p < 0.001 and r = 0.67, p < 0.001, respectively). The highest-scoring IDQOL items were "itching and scratching", and "child's mood". Poorer infants' QoL was associated with more serious AD (B = 2.56; 95% confidence interval (CI): 2.08-3.04), concomitant atopic disease (B = 3.86; 95% CI: 1.78-5.94), family history of atopic disease (B = 3.80; 95% CI: 1.84-5.77), older age of the child (B = 1.14; 95% CI: 0.20-2.07) and older age of the parent (B = 0.28; 95% CI: 0.04-0.53). Similarly, parents had poorer QoL if their infants had more severe AD (B = 2.56; 95% CI: 2.14-2.87), another atopic disease (B = 2.91; 95% CI: 0.99-4.84) or family history of atopic disease (B = 4.33; 95% CI: 2.57-6.09). Conclusions: Our results demonstrate that AD has a significant negative impact on infants' QoL as well as on QoL of their parents.
IntroductionPalmoplantar psoriasis (PPP) is a variant of psoriasis that affects the palms and/or soles. Although PPP is a disabling and therapeutically challenging condition, its epidemiology is poorly defined.AimTo assess the prevalence of PPP locations (palms, soles or both), and to analyse epidemiological and clinical characteristics of the disease.Material and methodsTwo bibliographic databases (MEDLINE and SCOPUS) were used as data sources searched from inception to October 2017. The selection of articles was limited to human subjects and English or French languages.ResultsA search resulted in a total of 293 articles, out of which 24 were utilized for the current systematic review and 21 for meta-analysis. All listed studies comprised a total of 2083 patients with PPP, with more males than females. According to the results of meta-analysis, majority of patients had the highest prevalence of both palms and soles involvement (95% CI: 47–67), with an almost equal prevalence showing palmar (21%; 95% CI: 13–30) or plantar (20%; 95% CI: 12–29) involvement. The most prevalent type of PPP was plaque/hyperkeratotic, followed by the pustular type.ConclusionsAlmost three-fifths (59%) of all PPP patients had involvement of both palms and soles, while exclusive palmar or plantar involvement was seen in 21% and 20% of patients, respectively. Future research should be performed to elucidate basic epidemiological and clinical characteristics of PPP, which would be helpful for proper consideration of this condition.
Prognoza i izbor terapije adenokarcinoma prostate (ADKP) direktno zavise od brojnih prediktivnih faktora, među kojima su najznačajniji zbirni histološki gradus tumora (Gleason score, koji predstavlja zbir prvog i drugog dominantnog histološkog gradusa) i klinički stadijum. Novija istraživanja u ove faktore ubrajaju i tkivni androgen status i neuroendokrinu diferencijaciju. Važnost prvog i drugog dominantnog histološkog gradusa naročito postaje značajan kod ADKP Gleason score-a 7. Smatra se da goru prognozu imaju ADKP višeg Gleason score-a, uznapredovalog kliničkog stadijuma, androgen nezavisni tumori i tumori koji pokazuju veći stepen neuroendokrine diferencijacije. Cilj rada je odrediti prediktivni značaj ADKP Gleason score-a 7 (3+4) i ADKP Gleason score-a 7 (4+3) u odnosu na klinički stadijum, tkivni androgen status i stepen fokalne neuroendokrine diferencijacije. Istraživanje je obuhvatilo 33 ADKP Gleason score-a 7, odnosno 26 (78,79%) ADKP 7 (3+4) i 7 (21,21%) ADKP 7 (4+3). Svi tumori su najčešće dijagnostikovani u stadijumu D2 kada su već postojale udaljene metastaze. ADKP Gleason score-a 7 (4+3) dijagnostikovani su u većem procentu u ovom stadijumu, među njima ima više androgen nezavisnih tumora i pokazuju veći stepen fokalne neuroendokrine diferencijacije. Svi dobijeni rezultati u saglasnosti su sa podacima iz literature i navode na zaključak da ADKP Gleason score-a 7 (4+3) imaju goru prognozu od ADKP Gleason score-a 7 (3+4).
Odre ivanje preoperativnih vrednosti serumskog prostata specifi nog antigena (PSA) predstavlja primarnu proceduru u dijagnozi razli itih patoloških promena u prostati (karcinoma prostate-KP, prostati ne intraepitelne neoplazije-PIN i benigne hiperplazije prostate-BHP), nakon ega sledi digitorektalni pregled i biopsija prostate kao zlatni standard. Me utim, visoka senzitivnost i niska specifi nost PSA testa u dijagnozi karcinoma prostate (KP) predstavlja problem u klini koj praksi. Cilj rada je utvrditi dijagnosti ke perfomanse serumskog PSA u dijagnozi KP, PIN i BHP. Ispitivanjem je obuhva eno 100 pacijenata podeljenih u tri grupe: 70 sa KP, 20 sa PIN i 10 sa BHP. Pacijenti sa PIN i BHP inili su kontrolnu grupu. Preoperativne vrednosti PSA odre ene su metodom Tandem-R, a na osnovu dobijenih rezultata pacijenti su podeljeni u grupe: 4-10, 11-20, 21-30, 31-40 i >40. Definitivna patohistološka dijagnoza postavljena je na rutinskim hematoksilin-eozin preparatima. Za svaku vrednost PSA kod KP odre ena je area ispod ROC krivulje, senzitivnost-SE i specifi nost-SP. Preoperativne vrednosti serumskog PSA kod pacijenata sa KP (medijan-35,82 ng/ml, min-6 ng/ml, max-960,40 ng/ml) zna ajno su ve e u odnosu na PIN (medijan-9,15 ng/ml, min-3,16 ng/ml, max-27,61 ng/ml) i BHP (medijan-8,68 ng/ml, min-0,80 ng/ml, max-31,20 ng/ml). Najbolje dijagnosti ke karakteristike PSA pokazuju se pri grani noj vrednosti koncentracije od 10 ng/ml (AUC=0,781; SE=92,9%; SP=63,3%; p<0,0001). Vrednost PSA je od velike pomo i u dijagnostici manifestnog, ali i po etnih formi KP. Sve vrednosti PSA iznad 10 ng/ml svakako treba da pobude zna ajnu sumnju na postojanje karcinoma prostate, pre nego na bilo koju drugu patohistološku promenu. Klju ne re i: karcinom prostate, prostata specifi ni antigen, senzitivnost, specifi nost.
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