How moderate white wine consumption modulates inflammatory cells infiltration of the ischemic myocardium following permanent coronary ligation was the key question addressed in this study. Male Sprague–Dawley rats were given either a combination of different white wines or water only for 28 days. Three peri-infarct/border zones and a control/nonischemic zone were analysed to determine the expression of myeloperoxidase (MPO) and cluster of differentiation 68 (CD68). Smaller expressions for both MPO and CD68 were found in all three peri-infarct zones of wine drinking animals (p < 0.001). There was no difference in the expression of leukocyte markers between animals drinking standard and polyphenol-rich white wine, although for CD68, a nonsignificant attenuation was noticed. In sham animals, a subepicardial MPO/CD68 immunoreactive “inflammatory ring” is described. Standard white wine consumption caused attenuation of the expression of MPO but not of CD68 in these animals. We conclude that white wine consumption positively modulates peri-infarct inflammatory infiltration.
Studies of the cardioprotective effects of wine are mainly focused on red wines, due to their much higher content of bioactive compounds relative to white wines. Although some studies indicate a cardioprotective effect of white wine, there is no clear consensus on the existence of additional benefits of white wine over ethanol. The aim of this study was to determine and compare the effects of moderate consumption of white wine and ethanol on the survival of rats subjected to surgically induced myocardial infarction (MI). Male Sprague Dawley rats (n = 74) were randomized into three groups: water only, white wine or a 13% v/v ethanol/water solution. After a four-week drinking period, MI was induced by ligating the left anterior descending artery. The survival rate was highest in the wine group (72.2%), and lowest in the water only group (47.8%). There was no statistically significant difference in survival between the ethanol and water groups. An analysis linking drinking volumes to survival outcomes revealed that lower ethanol consumption was more prevalent in rats that survived, indicating an upper limit for the protective effects of ethanol. An opposite finding was noticed in the wine group, where no deaths occurred in rats with an average daily white wine consumption of approximately 10 mL or more. We conclude that moderate consumption of white wine has a positive effect on survival after a myocardial infarction, which cannot be attributed only to ethanol, but also to other white wine constituents.
Rupture of the free wall of the left ventricle is a rare complication of acute myocardial infarction and in most cases ends fatally. The patient at the age of 60 was hospitalized in order to myocardial infarction. Coronarographically, occluded arteria coronaria circumflexa was determined, dilatation was unsuccessful and the continuation with drug therapy. Nine days later, he suddenly felt pressure in the chest and general weakness. Urgent echocardiography demonstrated cardiac tamponade and he was immediately sent to emergent surgery. The patient an excellente recovery and two weeks after was discharged home. DescriptionThe patient, aged 61, was brought to the emergency room by the ambulance after suffering from nausea, pressure in the chest, and a temporary loss of consciousness. It was the patient who was released from the hospital the same day, where he was treated for acute infarction without ST elevation with max. troponin I 3,012 μg/L. During hospitalization, the patient underwent coronary angiography and echocardiography. Coronarographically, occluded arteria coronaria circumflexa was determined, dilatation was attempted at the site of the occlusion but without success and the continuation of drug therapy was recommended.Other epicardial arteries were angiologically without significant stenosis. Echocardiography at the admission of the patient determined preserved systolic function of the left ventricle with dropout contractility of the basal part of the lateral wall and basal part of the inferior wall. The patient was treated with low molecular weight heparin, aspirin, angiotensin converting inhibitor, statin and betablocker.On the ninth day he was discharged in a stable condition. A few hours after he was discharged he suddenly felt pressure in the chest and general weakness. Upon the arrival in the emergency room the patient was pale, hypotensive, sweaty, the pressure in his chest was still present. Electrocardiogram showed the right bundle branch block, with no significant change in ST segment. The patient was resuscitated with intravenous fluids and inotropes.An urgent transthoracic echocardiography, bedside echo, was performed and it showed a pericardial effusion of the entire circumference, with signs that indicate tamponade shown in Figure 1, there was a collapse of the right atrium and ventricle. Color flow Doppler imaging failed to identify the area of the rupture. Then an urgent CT of the thorax was made. On that basis, the suspicion of the rupture of the ventricular free wall was confirmed. He was immediately sent to emergent surgery. The surgery was done straight away, it consisted of an evacuation of hemorrhagic effusion, hemostasis, and then a completion of the suture. The patient had an uneventful postoperative course and was discharged 14 days following the operation, the echocardiography on the day he was released showed a moderate pericardial effusion of up to 10 mm with a thinned inferior wall of the length of 8 mm. The checkup which took place 6 weeks after the general procedur...
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