Eosinophilic ulcer of the oral mucosa (EUOM), also known as traumatic ulcerative granuloma with stromal eosinophilia or Riga-Fede disease, is an uncommon benign self-limited lesion poorly described in the dermatological literature. It probably includes a spectrum of related disorders presenting as an ulcer with elevated indurated borders affecting the tongue, oral mucosa or lip. Histopathological findings are characteristic and consist of eosinophil-rich mixed infiltrates accompanied by a population of large mononuclear cells whose origins have been a matter of debate. Immunohistochemical studies of these cells have suggested a myofibroblastic or histiocytic origin. We present a 93-year-old woman with two episodes of self-healing ulcers on the upper lip and on the lingual mucosa, respectively. Histopathological findings on both biopsies were consistent with EUOM and showed the presence of large atypical CD30+ lymphocytes. Some recent reports have also shown positivity for the CD30 antigen, raising the possibility that a subset of EUOM could be included within the spectrum of CD30+ lymphoproliferative disorders. This finding most likely suggests that EUOM can represent another histological simulator of CD30+ lymphoproliferative disorders.
Several epidemiological, immunological and molecular studies have been carried out in sarcoidosis; however, there have been no studies on sarcoidal granulomatous dermatitis, its infectious causes and differential diagnoses.Using molecular biology techniques, the aim of this study was to evaluate the potential role of mycobacteria, bacteria and Leishmania in the aetiology of sarcoidal granulomatous dermatitis. MATERIALS AND METHODSA total of 48 skin biopsies, diagnosed as sarcoidal granulomatous dermatitis, were initially retrieved retrospectively . Only those cases with demonstrable negative results in cultures and special stains for bacteria, mycobacteria and fungi were included in the study.The 16S rRNA primers used were of broad range for all bacteria. Mycobacterium spp. DNA was detected with hsp65 and/or 16S-23S rRNA gene primers. FluoroType ® MTB (Hain Life Science, Nehren, Germany), a newly commercialized fluorescence-based molecular genetic test system, was also used for detection of Mycobacterium tuberculosis complex. The presence of Leishmania spp. DNA was analysed by amplifying the kinetoplast minicircle DNA sequence via real-time PCR.
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