Aggressive hydration with lactated Ringer solution can reduce the overall incidence of PEP, moderate to severe pancreatitis and hyperamylasemia, shorten the length of hospitalization and reduce pain.

Our study found that the regulation of autophagy could alter the progression of AP induced by L-arginine or cerulein plus LPS in mice.

Background and Aim: Currently, endoscopic drainage (ED) and percutaneous drainage (PD) are both widely used effective interventions in the management of patients with symptomatic pancreatic fluid collections (PFCs). This study aimed to compare the clinical effectiveness and safety of ED to those of PD in the treatment of PFCs. Methods: A prospective cohort study of PFC patients who underwent ED or PD was conducted between January 2009 and December 2017. In this study, the initial success rate, adverse events, intervention, requirement of surgical treatment, hospital mortality within 30 days, length of hospital stay, and expenses during hospitalization were monitored, and a follow-up investigation of treatment outcome was conducted. Long-term recovery, recurrence, and mortality were determined according to telephone follow up. Results: In total, 129 patients were included in the study; 62 patients underwent ED, and 67 patients underwent PD during the 8-year study period. Initial treatment success was considerably higher in patients whose PFCs were managed by ED than in patients whose PFCs were managed by PD (94.9% vs 65.0%, P = 0.003). The rate of procedural adverse events, reintervention, length of hospitalization, and expense were all higher in the PD group than in the ED group, but the long-term recovery rate and requirement of surgical intervention were not clearly different between patients who underwent the two treatment measures. Conclusion: ED of symptomatic PFCs was associated with higher rates of initial treatment success, lower rates of reintervention and adverse events, and a shorter hospital stay than PD of symptomatic PFCs. the Ethics Committee of the First Affiliated Hospital of Nanchang University. Financial support: The study design and data collection were funded by the National Natural Science Foundation of China (81760121) be given when symptoms, such as infection, abdominal pain, fistula, biliary or gastric outlet obstruction, anorexia, or weight loss, occur. Although nearly one-third of pancreatic pseudocysts dissolve on their own, some cysts, especially those larger than 6 cm in diameter, require intervention to prevent cystic infection, rupture, bleeding, and gastrointestinal or bile duct obstruction. 6,7 Walled-off pancreatic necrosis (WOPN) appears as a fibrous tissue-enclosed mixture of impurities and peri-inflammation of the peripancreatic leak. If WOPN is asymptomatic, it can be treated conservatively. However, if WOPN causes obstructive symptoms, and the Graduate Teaching Library Construction Project of Nanchang University (9202-0210210802). 1 Jianhua Wan and Dangyan Wu have equal contribution as first authors.