Abstract Physical fitness is a person’s ability to complete daily tasks without experiencing significant fatigue. Components of physical fitness consist of body composition, muscle flexibility, muscle strength, and cardiovascular fitness. Pre-clinical trials of herbal formula temulawak (Curcuma xanthorrhiza Roxb.), tumeric (Curcuma longa L.), and meniran (Phyllanthus niruri L.) can improve the fitness of test animals. The purpose of this study was to assess the safety and efficacy of temulawak, kunyit, and meniran herbal formulas for physical fitness. The research method in the form of quasi experimental pre and post with a placebo comparison involving 201 subjects divided into 2 groups. A total of 100 subjects in group I were given herbal medicine while group II as many as 101 subjects were given placebo for 6 weeks. The evaluation is based on the parameters of liver function, kidney, blood profile, and fitness component. The results showed that there were no significant changes (p≥0.05) in liver function, kidney function, blood profile, body composition, muscle flexibility, and muscle strength. Cardiovascular fitness in group I increased significantly (p<0.05) compared to group II. Temulawak, kunyit, and meniran formulas are safe for liver, kidney, blood profiles and can help improve physical fitness, especially cardiovascular fitness. Abstrak Kebugaran jasmani merupakan kemampuan seseorang menyelesaikan tugas sehari-hari tanpa mengalami kelelahan yang berarti. Komponen kebugaran jasmani terdiri dari komposisi tubuh, kelenturan otot, kekuatan otot, dan kebugaran kardiovaskular. Uji praklinis formula jamu temulawak (Curcuma xanthorrhiza Roxb.), kunyit (Curcuma longa L.), dan meniran (Phyllanthus niruri L.) dapat meningkatkan kebugaran hewan uji. Tujuan penelitian ini adalah menilai keamanan dan khasiat formula jamu temulawak, kunyit, dan meniran terhadap kebugaran jasmani. Metode penelitian berupa quasi experimental pre and post dengan pembanding plasebo yang melibatkan 201 subjek yang dibagi menjadi dua kelompok. Sebanyak 100 subjek kelompok I diberikan jamu sedangkan kelompok II sebanyak 101 subjek diberikan plasebo selama enam minggu. Evaluasi didasarkan atas parameter fungsi hati, ginjal, profil darah, dan komponen kebugaran. Hasil menunjukkan bahwa tidak terjadi perubahan bermakna (p≥0,05) pada fungsi hati, fungsi ginjal, profil darah, komposisi tubuh, kelenturan otot, dan kekuatan otot. Kebugaran kardiovaskular pada kelompok I mengalami peningkatan bermakna (p<0,05) dibanding kelompok II. Formula jamu temulawak, kunyit, dan meniran aman terhadap profil darah, hati dan ginjal serta dapat membantu meningkatkan kebugaran jasmani yaitu kebugaran kardiovaskular.
Borneo is known as the third largest island in the world, which has enormous biodiversity. For generations, the locals used to utilize surrounding plants to treat diseases and maintain their health. Hemorrhoid is one of the diseases which is often treated using medicinal plants. An ethnopharmacological study (RISTOJA) was conducted to find potential plants to be developed in Borneo island by interviewing selected local traditional healers. Identification of medicinal plants was performed, followed by descriptive and literature studies. The most important medicinal plants were defined using the calculation of frequency of citation (FC), use value (UV), and choice value (CV). In order to establish scientific evidence, a literature review was conducted focused on the benefit and toxicity using electronic search engines Pubmed, DOAJ, Scopus, and Google Scholar. The evidence was collected from empirical use to in-vitro, animal, or clinical studies. There were 49 species under 31 families used in herbal formula for hemorrhoids. Based on FC, UV, CV, and literature review, Curcuma longa L., Graptophyllum pictum (L.) Griff., Melastoma malabathricum L., and Cocos nucifera were confirmed to have enough scientific evidence regarding its safety and efficacy. Accordingly, those plants have the potential to be further developed.
Kualitas hidup merupakan salah satu penilaian tingkat keberhasilan suatu terapi. Kualitas hidup yang tinggi akan meningkatkan tingkat kesembuhan serta menurunkan morbiditas dan mortalitas penyakit. Studi ini dilakukan dalam rangka program Saintifikasi Jamu untuk mendapatkan informasi tentang ramuan jamu imunostimulan dalam meningkatkan kualitas hidup penderita HIV/AIDS. Penelitian ini dilakukan pada bulan Juni sampai Oktober tahun 2015 di Komisi Penanggulangan AIDS (KPA) Kabupaten Sragen. Ramuan jamu imunostimulan dapat diberikan sebagai terapi komplementer bersama terapi antiretroviral (ARV). Ramuan jamu yang digunakan adalah 14 gram rimpang temulawak (Curcuma xanthorrhiza), 14 gram temu mangga (Curcuma mangga), dan 14 gram herba meniran (Phyllantus niruri) dalam bentuk rebusan dibandingkan plasebo. Penelitian ini menggunakan metode quasi-experimental pre dan posttest dengan total 60 subjek penderita HIV/AIDS di Sragen. Intervensi dilakukan selama 28 hari dengan mengamati skor World Health Organization Quality of Life-HIV BREF (WHOQOL-HIV BREF) dan nilai CD4+. Hasil penelitian menunjukkan bahwa ramuan jamu imunostimulan menaikkan rata-rata skor WHOQOL-HIV BREF pada domain psikologi, kemandirian, dan kesehatan umum secara bermakna (p=0,014; 0,030; 0,003) dan mempertahankan nilai CD4+ subjek ramuan jamu. Ramuan jamu memberikan perubahan terhadap kualitas hidup subjek terutama pada domain psikologi, kemandirian, dan kesehatan umum serta mempertahankan nilai CD4+.
Obesity could be a risk factor for other diseases, especially degenerative diseases. The prevalence of obesity is beginning to elevate at developing countries. Indonesia has some traditional ingredients that can be used for alternatives in obesity problems. But there isnot valid evidence for the efficacy and safety of traditional herbs. This study was conducted to evaluate efficacy of Jamu formulation in comparison with orlistat and evaluate its safety. Jamu formula contains Guazuma ulmifolia dried leaves, Murraya paniculata dried leaves, Rheum officinale dried roots, and Sonchus arvensis dried leaves. The present study was an randomized clinical trial open label undertaken in 242 subjects of obesity for 56 days. The Jamu group received a glass twice daily and orlistat group received a capsule twice daily. Efficacy was assessed by the changes in body mass index, waist and mid-upper arm circumference. Safety was evaluated by SGOT, SGPT, ureum, dan creatinine. There was a significant decrease (p<0,05) in body mass index, waist and mid-upper arm circumference after intervention in both group. Changes of those parameters were not significantly different (p>0,05) between both groups. No significant alteration was seen in most of the SGOT, SGPT, ureum, dan creatinine in Jamu formula groups. This study showed Jamu formula was an equally effective, but safe alternative for obesity management. Abstrak Obesitas dapat menjadi faktor resiko penyakit lain khususnya penyakit degeneratif. Prevalensi obesitas mulai mengalamai peningkatan di negara berkembang. Indonesia memiliki beberapa ramuan tradisional yang dapat digunakan untuk alternatif dalam masalah obesitas. Namun belum ada bukti yang kuat mengenai khasiat dan keamanan dari ramuan tradisional yang ada. Tujuan penelitian ini untuk mengetahui manfaat dan keamanan ramuan jamu yang terdiri dari simplisia daun jati belanda, daun kemuning, akar kelembak, dan daun tempuyung dibandingkan orlistat. Penelitian ini menggunakan randomized clinical trial (RCT) open label dengan 242 subyek selama 56 hari.. Kelompok jamu diberikan segelas jamu 2 kali sehari, sedangkan kelompok orlistat diberikan satu kapsul sehari dua kali. Parameter yang digunakan untuk mengevaluasi khasiat formula jamu dan orlistat adalah indeks masa tubuh (IMT), lingkar perut (LP), lingkar lengan atas (LLA). Sedangkan penilaian keamanan digunakan parameter SGOT, SGPT, BUN, dan kreatinin. Pemberian jamu dan orlistat dapat menurunkan IMT, LP, LLA secara bermakna (p<0,05) jika dibandingkan dengan hari ke-0. Penurunan IMT, LP, LLA kelompok jamu dibandingkan orlistat dapat dikatakan setara (p>0,05). Kelompok jamu menujukkan nilai SGOT, SGPT, ureum, dan kreatinin dalam rentang normal. Penelitian ini menunjukkan bahwa ramuan jamu obesitas secara klinis, khasiatnya sebanding dengan orlistat dan aman setelah intervensi selama 56 hari.
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