The aqueous solubilities of 13 chlorinated derivatives of phenol (3,5-dichlorocatechol, 4,5-dichlorocatechol, 3,4,5-trichlorocatechol, tetrachlorocatechol, vanillin, 5-chlorovanillin, 6-chlorovanillin, 5,6-dichlorovanillin, 3-chlorosyringol, 3,5-dichlorosyringol, trichlorosyringol, 2-chlorosyringaldehyde, and 2,6-dichlorosyringaldehyde) were determined at 25 °C, by using a conventional shake-flask, batch contacting method with analysis by high-pressure liquid chromatography with UV detection. The liquid or supercooled liquid solubilities are satisfactorily correlated with the solute's LeBas molar volume, yielding structure-property relationships that may be useful for predictive purposes.
The aqueous solubilities and octanol-water partition coefficients of o-cymene, m-cymene, p-cymene, 2,3dichloro-p-cymene 2,5-dichloro-p-cymene, 2,3,6-trichloro-p-cymene and tetrachloro-p-cymene, were determined at 25 °C using GC and HPLC methods. These properties correlate well with additive LeBas molar volumes.
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