Introduction: Behcet's disease is a multisystemic disorder of unknown etiology. Vascular involvement is identified by the development of aneurysms and occlusion of the vessels. the current report aimed to discuss a case of Behcet disease presented with a bilateral pulmonary aneurysm. Case presentation: A 41-year-old woman presented with recurrent attacks of hemoptysis for two years. a chest computed tomography scan bilateral pulmonary artery aneurysm. Repeated bronchoscopy showed bleeding from the right lower lobe bronchus. She underwent a right-side thoracotomy with a right lower lobectomy. She was scheduled for left-side intervention as well. Before discharge, she was seen by a rheumatologist and was diagnosed with a case of Behcet disease. She developed attacks of massive hemoptysis (huge and bright blood) after two weeks which led to her passing away. Conclusion: Although it is rare, Behcet disease could involve major arteries and lead to fatal complications. Surgical intervention remained a viable option for the management.
Background: It is uncommon to have a hydatid cyst in the pulmonary artery. Typically, it results from an intracardiac cyst or a surgical cyst rupturing from a primary hepatic hydatid cyst. The objective of this meta-analysis is to quantitatively describe this rare disease. Methods: The electronic databases "Google Scholar" and "PubMed" were searched exhaustively for all pertinent publications in the English language. To explain the clinical parameters, the collected data was assembled and computationally processed. Its epidemiology was also mapped. Results: A total of 45 papers were initially found by the systematic search; however, only 16 studies that comprised 16 patients were included. Eight of the patients were male and eight were female. Hemoptysis, dyspnea, bloody sputum, vomiting, and shortness of breath were the clinically significant symptoms. Seventy-five percent of the patients had a history of hepatic hydatid disease, followed by three patients with primary lung cystic lesions and one patient with primary cardiac lesions. Severe pulmonary hypertension, septic shock, and massive hemoptysis all contributed to the death of three pulmonary echinococcosis patients. Conclusion: Localization of hydatid cysts inside the pulmonary artery is an uncommon but life-threatening condition. Surgery may be the only choice for some patients. The surgery outcomes depend on the patient's current condition and the severity of their underlying diseases.
Introduction: Although some recent studies have found that original and generic clopidogrel brands are acceptable and have the same pharmacokinetic and pharmacodynamic properties, there is insufficient evidence to compare the clinical effectiveness and safety of brand and generic clopidogrel. The current study aims to evaluate the clinical safety of brand and generic clopidogrel by comparing clinical outcomes in patients undergoing carotid endarterectomy (CEA). Method: This was a single centre, parallel-arm, phase III, open-label, and randomized group sequential trial. It was conducted to compare the clinical safety of a brand and three generic clopidogrel forms in patients who have undergone CEA. All enrolled subjects were treated perioperatively with dual antiplatelet (aspirin and clopidogrel). The involved participants were assigned randomly into four groups based on the type of clopidogrel. Safety parameters were measured, including haematoma, blood draining from drainage, mouth deviation, tongue deviation, and stroke. SPSS software was used to perform the data analysis. Results: The trial included 80 patients in total (20 patients per group). Thirty-one (38.8%) patients were male. The mean age of patients was 65.6 years (49–79). Eighteen (22.5%) patients had a history of previous coronary intervention, and seventeen (21.3%) had symptomatic carotid artery stenosis. Overall, Plavix or Piax combined with aspirin were linked to better clinical safety than the other two generic clopidogrel, as the amount of bleeding was nearly two times lower in patients treated with Plavix or Piax (270±92.39 and 271.5±80.60, respectively) compared to PlavigrelAwa or Plavineer (505.7±169.1 and 496.5±174.6, respectively) (P≤0.001). Conclusion: The findings of the current study showed diversity in clinical safety of different clopidogrel formulations that were provided perioperatively in CEA patients.
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