BackgroundInjury is a growing public health concern in China. Injury death rates are often higher in rural areas than in urban areas in general. The objective of this study is to compare the injury mortality rates in urban and rural residents in Hubei Province in central China by age, sex and mechanism of injury.MethodsUsing data from the Disease Surveillance Points (DSP) system maintained by the Hubei Province Centers for Disease Control and Prevention (CDC) from 2006 to 2008, injury deaths were classified according to the International Classification of Disease-10th Revision (ICD-10). Crude and age-adjusted annual mortality rates were calculated for rural and urban residents of Hubei Province.ResultsThe crude and age-adjusted injury death rates were significantly higher for rural residents than for urban residents (crude rate ratio 1.9, 95% confidence interval 1.8-2.0; adjusted rate ratio 2.4, 95% confidence interval 2.3-2.4). The age-adjusted injury death rate for males was 81.6/100,000 in rural areas compared with 37.0/100 000 in urban areas; for females, the respective rates were 57.9/100,000 and 22.4/100 000. Death rates for suicide (32.4 per 100 000 vs 3.9 per 100 000), traffic-related injuries (15.8 per 100 000 vs 9.5 per 100 000), drowning (6.9 per 100 000 vs 2.3 per 100 000) and crushing injuries (2.0 per 100 000 vs 0.7 per 100 000) were significantly higher in rural areas. Overall injury death rates were much higher in persons over 65 years, with significantly higher rates in rural residents compared with urban residents for suicide (279.8 per 100 000 vs 10.7 per 100 000), traffic-related injuries, and drownings in this age group. Death rates for falls, poisoning, and suffocation were similar in the two geographic groups.ConclusionsRates of suicide, traffic-related injury deaths and drownings are demonstrably higher in rural compared with urban locations and should be targeted for injury prevention activity. There is a need for injury prevention policies targeted at elderly residents, especially with regard to suicide prevention in rural areas in Central China.

Melatonin reportedly exerts beneficial effects to attenuate multiple organ dysfunction syndrome (MODS) in septic shock. Heatstroke resembles septic shock in many aspects. Thus, this study was performed on the anesthetized rats by using heat exposure to induce heatstroke-associated MODS. We evaluated the effect of melatonin, a versatile molecule synthesized in the pineal gland and in many organs, in heatstroke rats and showed that melatonin (0.2-5.0 mg/kg of body weight, i.v., immediately after the start of heat stress) significantly (i) attenuated hyperthermia, hypotension and hypothalamic ischemia and hypoxia, (ii) reduced plasma index of the toxic oxidizing radicals like nitric oxide metabolites and hydroxyl radicals, (iii) diminished plasma index of hepatic and renal dysfunction like creatinine, blood urea nitrogen, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and lactate dehydrogenase, (iv) attenuated plasma systemic inflammation response molecules like soluble intercellular and lesion molecule-1, E-selectin, tumor necrosis factor-alpha, interleukin (IL)-1β, and IL-6, (v) promoted plasma levels of an anti-inflammatory cytokine IL-10, (vi) reduced an index of infiltration of polymorphonuclear neutrophils in the lung like myeloperoxidase activity, and (vii) promoted the survival time to fourfold compared with the heatstroke alone group. Thus, melatonin could be a novel agent for the treatment of heatstroke animals or patients in the early stage.

, an outbreak of coronavirus disease 2019 (COVID-19) has occurred in Wuhan, China, and it has become a global pandemic currently. At the early stage, the Chinese government had adopted strict quarantine and hygiene measures, including disease detection and social distancing. Preventive behaviors, such as mask-wearing and hand-washing, had shown its importance in the control of the SARS (severe acute respiratory syndrome) and COVID-19 epidemic. 1-3 Previous studies suggest that individual's health behavior against disease was influenced by knowledge, 4 attitude, 5 and demographic factors. 6 This study investigated Chinese college students' health behavior toward COVID-19 during the quarantine period and identified its influencing factors. A cross-sectional questionnaire survey was conducted among Chinese college students between February 4, 2020, and February 21, 2020. The questionnaire consisted of 4 sections: (1) Demographic characteristics: gender, age, education level, major, residence, infection situation, contact situation, and parents' health condition. (2) Knowledge: included the general nature of virus, infection symptoms, and preventive measures (see Supplemental Table S1, available online). (3) Attitude: included perceived potential risk of infection and confidence on the final control of COVID-19 (see Supplemental Table S2, available online). (4) Health behavior: included hand-washing, mask-wearing, and social distancing. A 5-point Likert-type scale was used ranging from never to always. This study was approved by the Institution Review Board of Wuhan University (Approval Number: 2020YF0026). Informed consent was obtained from all participants. Among 1599 participants, 290 (18.14%) were living in Hubei Province, 902 (56.41%) were female, and 766 (47.90%) majored in medicine (Table 1). The mean knowledge score among participants was 8.63 (SD = 1.32, range = 0-10), and the mean attitude score was 22.51 (SD = 2.59, range = 6-30). Most college students reported a good health behavior in mask-wearing (94.06%), handwashing (91.13%), and social distancing (89.49%) during the epidemic. Results of binary logistic regression analysis on the influencing factors of health behavior are presented in Table 2. Gender, knowledge, and attitude toward COVID-19 were significantly associated with hand-washing. The odds ratio of female students was 1.93 times higher compared with

Zuo D, Wu Z, Li S. Age and intergenerational exchange among older parents in rural China Int J Soc Welfare 2011: 20: S30–S46 © 2011 The Author(s), International Journal of Social Welfare © 2011 Blackwell Publishing Ltd and the International Journal of Social Welfare. This study examined life‐course differences in the flow of intergenerational exchange in rural China. The analysis used longitudinal data and growth curve models to decompose the distinct effects of age and cohort on the receipt and provision of economic and instrumental support among elder parents and their adult children. The study highlighted the importance of examining the age trajectories of intergenerational support according to cohort‐specific experiences and family life stage. There was a net age effect on intergenerational exchange, with elder parents tending to receive more support from children over time. However, there were indeed significant cohort effects that represented socio‐historical variation in the relationship between aging and intergenerational exchange. The study also observed gender differences in the flow and growth of intergenerational exchange.

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ObjectivesThis study explored sexual knowledge, attitudes and practices of female only-child undergraduates and made a comparison with students with siblings.MethodsAnonymously completed questionnaires were received from 4,769 female undergraduates, recruited using randomized cluster sampling by type of university and students' major and grade. Multivariate logistic regression was used to assess the effects of only-child on sexual knowledge, attitudes and practices among female undergraduates.ResultsOf 4,769 female undergraduate students, 41.0% were only-child and 59.0% were students with siblings. Compared with students with siblings, only-child students scored higher on sex-related knowledge, were more inclined to agree with premarital sex, multiple sex partners, one-night stands, extramarital lovers and homosexuality, and were more likely to have a boyfriend and experience sexual intercourse (73.6% vs. 61.4%; 24.0% vs. 14.0%). Only-children were less likely to experience coercion at first sex and have first sexual intercourse with men not their “boyfriends” than children with siblings (3.3% vs. 6.4%; 20.7% vs. 28.8%). There were no significant differences on other risky sexual behaviors (e.g. multiple sex partners and inconsistent condom use) between the only-child students and students with siblings.ConclusionsSexual knowledge, attitudes and some practices of only-child female undergraduates were different from students with siblings. Intervention should be designed according to different requirements of only-children and non-only-children.

OBJECTIVE: To investigate the clinical value of dynamic contrast enhanced ultrasound (D-CEUS) in predicting the microvascular invasion (MVI) of hepatocellular carcinoma (HCC). PATIENTS AND METHODS: In this retrospective study, 16 patients with surgery and histopathologically proved HCC lesions were included. Patients were classified according to the presence of MVI: MVI positive group (n = 6) and MVI negative group (n = 10). Contrast enhanced ultrasound (CEUS) examinations were performed within a week before surgery. Dynamic analysis was performed by VueBox ® software (Bracco, Italy). Three regions of interests (ROIs) were set in the center of HCC lesions, at the margin of HCC lesions and in the surrounding liver parenchyma accordingly. Time intensity curves (TICs) were generated and quantitative perfusion parameters including WiR (wash-in rate), WoR (wash-out rate), WiAUC (wash-in area under the curve), WoAUC (wash-out area under the curve) and WiPi (wash-in perfusion index) were obtained and analyzed. RESULTS: All of HCC lesions showed arterial hyperenhancement (100 %) and at the late phase as hypoenhancement (75 %) in CEUS. Among all CEUS quantitative parameters, the WiAUC and WoAUC were higher in MVI positive group than in MVI negative group in the center HCC lesions (P <  0.05), WiAUC, WoAUC and WiPI were higher in MVI positive group than in MVI negative group at the margin of HCC lesions. WiR and WoR were significant higher in MVI positive group. CONCLUSIONS: D-CEUS with quantitative perfusion analysis has potential clinical value in predicting the existence of MVI in HCC lesions.