Microparticles have a demonstrated value for drug delivery systems. The attempts to develop this technology focus on the generation of featured microparticles for improving the function of the systems. Here, we present a new type of microparticles with gelatin methacrylate (GelMa) cores and poly(L-lactide-co-glycolide) (PLGA) shells for synergistic and sustained drug delivery applications. The microparticles were fabricated by using GelMa aqueous solution and PLGA oil solution as the raw materials of the microfluidic double emulsion templates, in which hydrophilic and hydrophobic actives, such as doxorubicin hydrochloride (DOX, hydrophilic) and camptothecine (CPT, hydrophobic), could be loaded respectively. As the inner cores were polymerized in the microfluidics when the double emulsions were formed, the hydrophilic actives could be trapped in the cores with high efficiency, and the rupture or fusion of the cores could be avoided during the solidification of the microparticle shells with other actives. The size and component of the microparticles can be easily and precisely adjusted by manipulating the flow solutions during the microfluidic emulsification. Because of the solid structure of the resultant microparticles, the encapsulated actives were released from the delivery systems only with the degradation of the biopolymer layers, and thus the burst release of the actives was avoided. These features of the microparticles make them ideal for drug delivery applications.

The relatively higher temperature of the tumor site and the temperature responsive shape transition of pNIPAM hydrogel make the controllable drug release possible for oncotherapy.

Calcium carbonate/natural rubber (NR) latex nanometer composites were prepared by adding nanometer CaCO 3 whose surface had been treated to natural rubber latex (NRL) before sulfuration. The physical, thermooxidative aging, and thermal degradation properties and the ultra-microstructure were analyzed with a multipurpose material testing meter, a thermal analysis meter and a Philips XL-30 SEM, respectively. The results showed that the structures and properties of nanometer composites could be clearly improved by NRL mixed with surface-treated nanometer CaCO 3 . The physical properties of the nanometer composites were best when the content of surface treatment agent was 2.5% (to nanometer CaCO 3 ), the nanometer CaCO 3 /NRL content was 3:100, and the stirring time for treating the surface of the nanometer CaCO 3 was 20 min. Simultaneously, the thermooxidative aging resistance of the nanometer composites also was significantly improved.

Based on requirement of intensity and thickness for the tubular nonwoven composite material by the big pipeline rehabilitation, the preparation and properties of the tubular nonwoven composite material were researched. To add fabric to reinforce the tubular nonwoven composite material; two pieces or more of the reinforced nonwoven were designed, so the structure of the tubular nonwoven composite material with the seams in circle direction equidistant, the structure of the tubular nonwoven composite material with many seams is symmetry, during inversion, the collecting of the stress of the single seam can be avoided, so the crazing of the seam is prevented; when the reinforced nonwoven is coverd film, at its two sides the areas for sewing were obligated, the difficulty of the sewing is decreased, the efficiency of the sewing is increased, and the thickness of the seam is decreased, the film jointing of the seam become more easy, the airproof of the tubular nonwoven composite material can be guaranteed. The test result shows that mechanical property, width and airproof property can meet the design requirement, and the corrosion resistance can meet the requirement of the standard.