The fatty acid components in C. odorata with NF-κB inhibitory activity could explain the anti-inflammation property of this plant in traditional medicine. This study could also contribute to the better use of C. odorata for human health care.
A new stereoisomer Meso-araguspongine C together with nine reported macrocyclic bis-quinolizidine alkaloids araguspongines A, C, E, L, N-P, petrosin, and petrosin A were isolated from marine sponge Xestospongia muta. Stereochemistry of meso-araguspongine C (2) and araguspongines N-P (3-5) were established by their NMR data and conformational analyses. Both araguspongine C (1) and meso-araguspongine C (2) exhibited great cytotoxic activity towards HepG-2, HL-60, LU-1, MCF-7, and SK-Mel-2 human cancer cells (IC in the range of 0.43-1.02 μM). At a concentration of 20 μM, isolated compounds (1-10) also showed modest inhibitory effects (from 7.6 to 40.8%) on the NO production in LPS activated RAW264.7 macrophages.
Four new cucurbitane- type triterpene glycosides, charantosides D-G (1–4) were isolated from a methanol extract of Momordica charantia fruits. The structures of these compounds were determined by chemical and spectroscopic methods to be (19 R)-5 β,19-epoxy-25-methoxycucurbita-6,23-diene-3 β,19-diol 3- O-β-D-glucopyranoside, (19 R)-5 β,19-epoxy-25-methoxycucurbita-6,23-diene-3 β,19-diol 3- O-β-D-allopyranoside, 7 β-methoxycucurbita-5,23 E,25-triene-3 β-ol 3- O-β-D-allopyranoside, and 3 β,7 β-dihydroxycucurbita-5,23 E,25-triene-19-al 3- O-β-D-allopyranoside.
Three new constituents (1-3) were isolated from the whole plant of Balanophora laxiflora. Their chemical structures were elucidated by extensive analysis of high-resolution electrospray ionization mass spectrometry and nuclear magnetic resonance spectroscopy. Absolute configurations of new compounds were determined by circular dichroism spectra and modified Mosher's method. The isolated compounds weakly inhibited on both NO production and COX-2 mRNA expression in RAW264.7 macrophages.
Two new sesquiterpenes, named dysinidins A-B (3, 4) along with two known sesquiterpenes, furodysinin lactone (1) and O-methyl furodysinin lactone (2), were isolated from the Vietnamese marine sponge Dysidea fragilis. Their structures were determined by 1D-and 2D-NMR spectroscopies and HR ESI MS, as well as by comparison with reported literature data. None of compounds showed inhibitory growth of human lung cancer cell lines, A-549 and H-1975 (IC 50 > 30μM).
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