A metal-free method for the regioselective synthesis of 2-thiolated quinolines from quinoline N-oxides in water at room tempera-ture is developed. The reaction is conducted by using benzenethiols as thiolation reagents...
A Pd-catalyzed annulation between 1-(2-iodophenyl)-1H-indoles and sodium difluorochloroacetate has been developed to synthesize 10H-indolo[1,2-a]indol-10-one derivatives via C-H bond activation and difluorocarbene transfer. Our route enables facile access to targeted products...
An efficient synthesis of α‐oxoalkyl ketones is described. The current method is the coupling reaction of phenyl vinyl azides and cyclic ethers under metal‐free conditions. The reaction is conducted with KI as the additive and TBHP (70 % solution in water) as the oxidant at 60 °C for 12 h. A wide range of α‐oxyalkylated ketones with broad functionalities has been synthesized in moderate to good yields.
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