Deposition in the oropharyngeal geometry was consistently approximately 11% of the emitted dose throughout the entire range of flow rates. Such consistency in deposition was due to the fact that mass median aerodynamic diameter (MMAD) varied inversely as the square root of the flow rate, resulting in an approximately constant value for the inertial deposition parameter. Thus, an increase in flow rate, which would increase the momentum of a fixed particle size and generally lead to higher oropharyngeal deposition, was almost exactly counterbalanced by the accompanying decrease in MMAD. Results also showed that deposition in the oropharyngeal region was unaffected by other potentially relevant factors such as different airflow ramp rates, inhalation time, ambient temperature and relative humidity, and device orientations.
Rapid vaporization of pharmaceuticals coated as thin films on substrates is an efficient way of generating drug aerosols. By controlling the film thickness, the amount of aerosol decomposition can be minimized to produce high purity aerosols.
Delivering therapeutic compounds via the lungs presents potential advantages relative to other routes of administration. Depending on the compound and the disease state, these advantages may include: non-invasive medication delivery, ease of administration, higher bioavailability leading to dose sparing and lower systemic toxicity, potentially greater blood–brain barrier penetration and rapid pharmacodynamic effect. The practice of inhaling drugs has been around for centuries, including both medical and recreational usage. It is only more recently that formal clinical development programs have been undertaken specifically to use medication delivery via the lung to achieve systemic blood levels for the treatment of CNS disorders. At present, there are several CNS therapies being developed for pulmonary administration, with some of those programs at or near the marketing authorization stage. While there are still regulatory hurdles before these therapies can be put into practice, the success of these programs thus far demonstrates the scientific viability of inhalation therapies for treating CNS disorders.
Technical standards indicate that the upper limit on inhaled T(wb) for safety and tolerability is 50°C, and inhalation at that temperature can be sustained for 1 h. Peak values of T(wb) from the Staccato system are well below that threshold, approximately 30°C at nominal conditions and approximately 40°C at a combination of extreme conditions. Moreover, the peak lasts for only a few seconds, well under the time limit of 1 h. These results suggest that aerosols generated with the Staccato system will be safe and well tolerated.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.