We applied second-order blind identification (SOBI), an independent component analysis method, to MEG data collected during cognitive tasks. We explored SOBI's ability to help isolate underlying neuronal sources with relatively poor signal-to-noise ratios, allowing their identification and localization. We compare localization of the SOBI-separated components to localization from unprocessed sensor signals, using an equivalent current dipole modeling method. For visual and somatosensory modalities, SOBI preprocessing resulted in components that can be localized to physiologically and anatomically meaningful locations. Furthermore, this preprocessing allowed the detection of neuronal source activations that were otherwise undetectable. This increased probability of neuronal source detection and localization can be particularly beneficial for MEG studies of higher-level cognitive functions, which often have greater signal variability and degraded signal-to-noise ratios than sensory activation tasks.

No abstract

We recently demonstrated that second-order blind identification (SOBI), an independent component analysis (ICA) method, can separate the mixture of neuronal and noise signals in magnetoencephalographic (MEG) data into neuroanatomically and neurophysiologically meaningful components. When the neuronal signals had relatively higher trial-to-trial variability, SOBI offered a particular advantage in identifying and localizing neuronal source activations with increased source detectability (A. C. Tang et al., 2002, Neural Comput. 14, 1827-1858). Here, we explore the utility of SOBI in the analysis of temporal aspects of neuromagnetic signals from MEG data. From SOBI components, we were able to measure single-trial response onset times of neuronal populations in visual, auditory, and somatosensory modalities during cognitive and sensory activation tasks, with a detection rate as high as 96% under optimal conditions. Comparing the SOBI-aided detection results with those obtained directly from the sensors, we found that with SOBI preprocessing, we were able to measure, among a greater proportion of trials, single-trial response onset times that are above background neuronal activity. We suggest that SOBI ICA can improve our current capability in measuring single-trial responses from human subjects using the noninvasive brain imaging method MEG.

As university-level distance learning programs become more and more popular, and software engineering courses incorporate eXtreme Programming (XP) into their curricula, certain challenges arise when teaching XP to students who are not physically co-located. In this paper, we present the results of a three-year study of such an online software engineering course targeted to graduate students, and describe some of the specific challenges faced, such as students' aversion to aspects of XP and difficulties in scheduling. We discuss our findings in terms of the course's educational objectives, and present suggestions to other educators who may face similar situations.

The high cost of operating large computing installations has motivated a broad interest in reducing the need for human intervention by making systems self-managing. This paper explores the extent to which control theory can provide an architectural and analytic foundation for building self-managing systems, either from new components or layering on top of existing components. Further, we propose a deployable testbed for autonomic computing (DTAC) that we believe will reduce the barriers to addressing key research problems in autonomic computing. The initial DTAC architecture is described along with several problems that it can be used to investigate.