The applicability of water-based reflux and room temperature synthesis processes for the production of CPO-27 MOFs, suitable for NO delivery applications, is investigated. NO adsorption, storage and release performance of products obtained under reflux conditions are comparable to those of equivalent samples synthesised from traditional solvothermal methods at small scale. Products obtained from room temperature processes show lower NO release capability, although the quantities that are released are still more than adequate for biomedical applications. Results also reveal differences for the first time in NO uptake, storage and release depending on whether Zn, Ni or Mg is employed. The results indicate that while the crystallinity of CPO-27(Zn) and CPO-27(Mg) is not affected by moving to lower temperature methods, the crystallinity of CPO-27(Ni) is reduced. Particle morphology and size is also affected. The low temperature processes are successfully demonstrated at 20 L and 100 L scale and the main problems encountered during scale-up are outlined. The 100 L scale is in itself an appropriate production scale for some niche biomedical products. Indeed, results indicate that this synthesis approach is suitable for commercial production of MOFs for this application field. We also confirm that BET surface area from nitrogen adsorption at 77 K is not a good indicator for successful adsorption of NO.

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Nitric oxide release from CPO-27 MOFs and the resulting coronary artery relaxation response are tuned by isomorphous substitution of Ni into the MOF framework.

Two salts of the chlorhexidine di-cation (H2CHx2+) – (H2CHx)(SO4)·3H2O and (H2CHx)(CO3)·4H2O – have been synthesised and characterised crystallographically.

The applicability and capability of sorption techniques for comprehensive surface characterization of fibres including natural fibres, ligno-cellulosic fibres, cellulose nano-fibrils (CNFs), and cellulose nano-crystals (CNCs) are well established. This study provides comprehensive surface characterization of recycled and non-recycled cellulose-based bathroom tissues including the dispersive and specific surface-free energy, acid-base properties, and BET-specific surface area, as well as complete water sorption and desorption behaviours at ambient temperature.