Simulation studies using susceptible-infectious-recovered models were conducted to estimate individuals' risk of infection and time to infection in small-world and randomly mixing networks. Infection transmitted more rapidly but ultimately resulted in fewer infected individuals in the small-world, compared with the random, network. The ability of measures of network centrality to identify high-risk individuals was also assessed. "Centrality" describes an individual's position in a population; numerous parameters are available to assess this attribute. Here, the authors use the centrality measures degree (number of contacts), random-walk betweenness (a measure of the proportion of times an individual lies on the path between other individuals), shortest-path betweenness (the proportion of times an individual lies on the shortest path between other individuals), and farness (the sum of the number of steps between an individual and all other individuals). Each was associated with time to infection and risk of infection in the simulated outbreaks. In the networks examined, degree (which is the most readily measured) was at least as good as other network parameters in predicting risk of infection. Identification of more central individuals in populations may be used to inform surveillance and infection control strategies.
We consider a stochastic model for the spread of an epidemic amongst a population split into m groups, in which infectives move among the groups and contact susceptibles at a rate which depends upon the infective's original group, its current group, and the group of the susceptible. The distributions of total size and total area under the trajectory of infectives for such epidemics are analysed. We derive exact results in terms of multivariate Gontcharoff polynomials by treating our model as a multitype collective Reed–Frost process and slightly adapting the results of Picard and Lefèvre (1990). We also derive asymptotic results, as each of the group sizes becomes large, by generalising the method of Scalia-Tomba (1985), (1990).
We consider a stochastic model for the spread of an epidemic amongst a population split into m groups, in which infectives move among the groups and contact susceptibles at a rate which depends upon the infective's original group, its current group, and the group of the susceptible. The distributions of total size and total area under the trajectory of infectives for such epidemics are analysed. We derive exact results in terms of multivariate Gontcharoff polynomials by treating our model as a multitype collective Reed–Frost process and slightly adapting the results of Picard and Lefèvre (1990). We also derive asymptotic results, as each of the group sizes becomes large, by generalising the method of Scalia-Tomba (1985), (1990).
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