Hooded rats were given chloroquine phosphate (Aralen) over an eight month period during which regular indirect ophthalmoscopic examinations were performed. When retinal or anterior ocular changes were observed in poisoned rats, retinas were prepared for electron microscopy. Significant ultrastructural changes were localized in the inner segments of the receptor cells, where mitochondrial swelling, disappearance of theciliary process and disorganization of the endoplasmic reticulum were observed. Observations were consistent with previous clinical, light microscopic and electroretinographic findings.
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