Apatite Nucleus (AN) was attached on the surfaces of maghemite (γ-Fe2O3) particles and soaked them in SBF. By this treatment, formation of bonelike apatite was induced by AN and the apatite covered the whole surface of the γ-Fe2O3 particles. Urease was immobilized on the surfaces of microcapsules and collected by a neodymium magnet. The immobilized urease has an ability of a urea decomposition in an aqueous solution.
When pH or temperature of simulated body fluid (SBF) is raised, fine particles of calcium phosphate are precipitated. We found that this fine particle actively induces hydroxyapatite from body fluid or SBF and named the particle Apatite Nucleus (AN). In this study, we attached AN on the surface of γ-Fe2O3 nanoparticles and soaked them in SBF. By this treatment, hydroxyapatite was induced from AN and covered the whole surface of the γ-Fe2O3 nanoparticles, then hydroxyapatite microcapsule encapsulated γ-Fe2O3 was fabricated. We dispersed the microcapsules in urease solution, and collected the microcapsules by neodymium magnet. It was indicated that the urease was adsorbed to the hydroxyapatite microcapsules and collected by the magnetism of γ-Fe2O3 successfully.
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