The direct cross‐aldol reaction of alkynyl aldehydes catalyzed by a trifluoromethylated diarylprolinol provides a practical route for the highly enantioselective synthesis of chiral β‐alkynyl‐β‐hydroxy aldehydes. Good anti selectivity and excellent enantioselectivity were obtained in the reactions of silylpropynals, which afford synthetically useful chiral building blocks.
Theasymmetric cross-aldolreactionofd ichloroacetaldehyde with aldehyde pronucleophiles proceeds in the presence of at rifluoromethyl-substituted diarylprolinol to afford g,g-dichloro-b-hydroxy aldehydesi ng ood yield with excellent enantioselectivity.T he obtained products are useful synthetic intermediates;they were successfully converted to form chiral alkynes anddichloroalkenes. Figure 2. Proposed transition state between enaminei ntermediate of an aldehyde pro-nucleophile and dichloroacetaldehyde
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.