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Case Modern medicine's technological advancements recognize the contributions of traditional and complementary medicine. Combining Kampo medicine, antihypertensive agents, and lifestyle changes can be an effective, holistic treatment approach for patients with hypertension, frequently accompanied by impaired mental health and quality of life. This case concerns a patient with hypertension who demonstrated poor lifestyle habits, mental stress, and intolerance to antihypertensive agents. The patient was treated with yokukansankachimpihange therapy fortified with bisoprolol and lifestyle changes including dietary modifications, sleep hygiene, and exercise (including street dance). Outcome The patient's ambulatory systolic blood pressure decreased from 174.6 ± 16.2 (mean ± SD) to 134 ± 10.4 mm Hg after initiating the fortified yokukansankachimpihange therapy. The patient also experienced improvements in heart palpitations, shortness of breath, anxiety, constipation, and headache severity. Conclusion Fortified therapy is an efficacious, advanced integrated medicine approach that can be used to treat patients with hypertension.