Background: This study was conducted to evaluate the relationship of job stress, burnout, and resilience of 271 nurses who worked alternately at a university hospital in South Korea Province and a state-designated inpatient ward for COVID-19 in Korea. Methods: The study sample included nurses who worked at a university hospital in South Korea, during the period between February 2020 and May 2021. The participants (n = 271) responded to an online survey between April 2021 and 12 May 2021. The questionnaire included information related to job stress, burn out, and resilience. Results: In phase 1 of regression, job stress had a significant negative effect on resilience of recovery (β = −0.397, p < 0.001). In phase 2, job stress had a significant positive effect on burnout (β = 0.513, p < 0.001). In phase 3, resilience had a significant negative effect on burnout (β = −0.459, p < 0.001). Seventy-five percent of burnout was directly associated with job stress, while 25% of burnout was indirectly associated through mediated effects, through resilience. Conclusions: The promotion of resilience would not only serve as the basis for active coping in situations where burnout and stress are severe, but also serve as a basic driving force for actively overcoming them. Further study to cope with stress and reduce burnout at the organizational level should be conducted.
Lasers stabilized to vacuum-gap Fabry-Pérot optical reference cavities display extraordinarily low noise and high stability, with linewidths much less than 1 Hz. These lasers can expand into new applications and ubiquitous use with the development of compact, portable cavities that are manufacturable at scale. Here we demonstrate an 8 mL volume Fabry-Pérot cavity constructed with mirrors that are fabricated lithographically with finesse near 1 million. A laser locked to the cavity exhibits phase noise limited by the cavity thermal noise for offset frequencies ranging from 1 Hz to ≈ 1 kHz, with a fractional frequency stability of 7×10 −15 at 1 second. Furthermore, the use of microfabricated mirrors allows us to expand the design space of centimeter-scale cavities, and we explore the noise implications of pushing towards cavity volumes of 2 mL or less.
Liver failure is an outcome of chronic liver disease caused by steatohepatitis and cholestatic injury. This study examined substance P (SP) effect on liver injury due to cholestatic stress caused by excessive bile acid (BA) accumulation. Chenodeoxycholic acid (CDCA) was added to HepG2 cells to induce hepatic injury, and cellular alterations were observed within 8 h. After confirming BA-mediated cellular injury, SP was added, and its restorative effect was evaluated through cell viability, reactive oxygen species (ROS)/inflammatory cytokines/endothelial cell media expression, and adjacent liver sinusoidal endothelial cell (LSEC) function. CDCA treatment provoked ROS production, followed by IL-8 and ICAM-1 expression in hepatocytes within 8 h, which accelerated 24 h post-treatment. Caspase-3 signaling was activated, reducing cell viability and promoting alanine aminotransferase release. Interestingly, hepatocyte alteration by CDCA stress could affect LSEC activity by decreasing cell viability and disturbing tube-forming ability. In contrast, SP treatment reduced ROS production and blocked IL-8/ICAM-1 in CDCA-injured hepatocytes. SP treatment ameliorated the effect of CDCA on LSECs, preserving cell viability and function. Collectively, SP could protect hepatocytes and LSECs from BA-induced cellular stress, possibly by modulating oxidative stress and inflammation. These results suggest that SP can be used to treat BA-induced liver injury.
We develop and demonstrate a compact (less than 6 mL) portable Fabry-Pérot optical reference cavity. A laser locked to the cavity is thermal noise limited at 2 × 10−14 fractional frequency stability. Broadband feedback control with an electro-optic modulator enables near thermal-noise-limited phase noise performance from 1 Hz to 10 kHz offset frequencies. The additional low vibration, temperature, and holding force sensitivity of our design makes it well suited for out-of-the-lab applications such as optically derived low noise microwave generation, compact and mobile optical atomic clocks, and environmental sensing through deployed fiber networks.
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