Cortisol is a biomarker for stress monitoring; however, the biomedical and clinical relevance is still controversial due to the complexity of cortisol secretion mechanisms and their circadian cycles as well as environmental factors that affect physiological cortisol level, which include individual mood and dietary intake. To further investigate this multifaceted relationship, a human pilot study examined cortisol concentration in sweat and saliva samples collected from 48 college-aged participants during aerobic exercise sessions along with mental distress and nutrition surveys. Enzyme-linked immunosorbent assays determined highly significant differences between apocrine-dominant sweat (AP), saliva before exercise (SBE), and saliva after exercise (SAE) cortisol concentration (AP-SBE: p = 0.0017, AP-SAE: p = 0.0102). A significantly greater AP cortisol concentration was detected in males compared to females (p = 0.0559), and significant SAE cortisol concentration differences were also recorded between recreational athletes and non-athletes (p = 0.044). However, Kessler 10 Psychological Distress Scale (K10) scores, an examination administered to deduce overall wellness, provided no significant differences between males and females or athletes and non-athletes in distress levels, which statistically signifies a direct relationship to cortisol was not present. For further analysis, dietary intake from all participants was considered to investigate whether a multiplexed association was prevalent between nutrition, mood, and cortisol release. Significant positive correlations between AP cortisol, SAE cortisol, K10 scores, and fat intake among female participants and athletes were discovered. The various machine learning algorithms utilized the extensive connections between dietary intake, overall well-being, sex factors, athletic activity, and cortisol concentrations in various biofluids to predict K10 scores. Indeed, the understanding of physiochemical stress response and the associations between studied factors can advance algorithm developments for cortisol biosensing systems to mitigate stress-based illnesses and improve an individual’s quality of life.

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Autism Spectrum Disorder (ASD) starts showing symptoms in the early formative years of an individual, affecting brain development and negatively impacting social and communication skills. Subjective diagnostic methods for ASD detection require lengthy questionnaires, trained medical personnel, and occupational therapists, and are subject to observer variability. Recent years have seen a rise in the usage of machine learning techniques for detecting ASD, which stems from a requirement for objective and accurate detection methods. This research analyzes the performance of various deep convolutional architectures for the detection of ASD. The primary objective of this work is to select a method capable of performing automatic feature extraction and classification with a relatively high degree of accuracy. Several experiments were conducted with different stateof-the-art deep architectures, out of which the ResNet50 performed the best, with an average accuracy of 81%. The performances of these architectures were analyzed in terms of precision, recall, and accuracy.

In surface mount technology (SMT), mounted components on soldered pads are subject to move during reflow process. This capability is known as self-alignment and is the result of fluid dynamic behaviour of molten solder paste. This capability is critical in SMT because inaccurate self-alignment causes defects such as overhanging, tombstoning, etc. while on the other side, it can enable components to be perfectly self-assembled on or near the desire position. The aim of this study is to develop a machine learning model that predicts the components movement during reflow in and -directions as well as rotation. Our study is composed of two steps: (1) experimental data are studied to reveal the relationships between self-alignment and various factors including component geometry, pad geometry, etc. (2) advanced machine learning prediction models are applied to predict the distance and the direction of components shift using support vector regression (SVR), neural network (NN), and random forest regression (RFR). As a result, RFR can predict components shift with the average fitness of 99%, 99%, and 96% and with average prediction error of 13.47 (µ ), 12.02 (µ ), and 1.52 (deg.) for component shift in , , and rotational directions, respectively. This enhancement provides the future capability of the parameters' optimization in the pick and placement machine to control the best placement location and minimize the intrinsic defects caused by the self-alignment.