Background: While the medial meniscal posterior horn (MMPH) is reported to bear a considerable portion of overall load on the knee joint, including compressive and shear forces, no study has yet investigated the relationship between the MMPH and posterior tibial slope (PTS), which is a geometric factor associated with the shear force component in the presence of a compressive load in the knee joint. Hypothesis/Purpose: The purpose was to investigate the relationship between the PTS and MMPH tears in patients without ligamentous injury. It was hypothesized that the PTS is greater in patients with MMPH tears as compared with those without. Study Design: Cohort study; Level of evidence, 3. Methods: From March 2015 to December 2018, 159 patients with isolated MMPH tears and 60 patients without any pathologic findings on magnetic resonance imaging (control group) were included in this study. The PTS in the affected and contralateral knees was compared between the groups, which were statistically matched according to baseline characteristics (ie, age, sex, body mass index, radiographic osteoarthritis grade according to the Kellgren-Lawrence scale, and hip-knee-ankle angle) via the inverse probability of treatment weighting method. Furthermore, the MMPH tear group was subdivided according to meniscal tear patterns; these subgroups were then compared with the control group. Results: The mean PTS was significantly greater in the MMPH tear group than in the control group (affected knee: MMPH tear group, 7.0°± 3.4° [mean ± SD]; control group, 5.2°± 2.1°, P < .001; contralateral knee: MMPH tear group, 6.7°± 3.3°; control group, 4.7°± 2.2°, P < .001). The mean PTS in each subgroup also tended to be greater than that in the control group. In the receiver operating characteristic curve analysis, the cutoff point of the PTS discriminating between the MMPH tear and control groups was 6.6° for the affected knee (sensitivity, 55.3%; specificity, 75.0%) and 5.5° for the contralateral knee (sensitivity, 61.0%; specificity, 76.7%). Conclusion: An increased PTS is strongly associated with an increased incidence of MMPH tears and less affected by the meniscal tear patterns.

Column chromatographic technology was applied to isolate six purified ursane triterpenoids from the calyx of Fragaria ananassa and they were identified on the basis of spectroscopic methods to be ursolic acid (1), pomolic acid (2), 2-oxo-pomolic acid (3), 3-O-acetyl pomolic acid (4), fupenzic acid (5) and euscaphic acid (6). This is the first study in which these compounds have been isolated from the calyx of F. ananassa. Compared to a well-known inhibitor, α-arbutin, compounds 2-6 showed a significant decrease in intracellular melanin content in B16-F10 cells, and in culture media melanin.

No abstract

BackgroundBone mineral density (BMD) is known to have a positive correlation with lean body mass. Several studies have also reported the positive correlation between muscle power and BMD. From this point of view, we hypothesized BMD of lumbar spine to have a positive correlation with muscle mass.MethodsSeventy-nine female patients aged between 60 and 75 years old and who underwent magnetic resonance imaging (MRI) and BMD studies were included. Muscle mass in spine MRI was defined by the sum of the average muscle area of three axial images for each disc level. Lumbosacral muscle is the sum of paraspinal muscle and psoas muscle.ResultsIn correlation analysis, paraspinal muscle mass showed positive correlation with BMD of lumbar spine. Lumbosacral muscle mass showed positive correlation with BMD of trochanteric area of the femur. However, BMD of other area showed no significant correlation with muscle mass.ConclusionsTherefore, postmenopausal women older than 60 years with a well developed spine muscle mass, have a high BMD.

The authors declared that they have no conflicts of interest in the authorship and publication of this contribution. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto.