The Eukaryotic Pathogen, Vector and Host Informatics Resource (VEuPathDB, https://veupathdb.org) represents the 2019 merger of VectorBase with the EuPathDB projects. As a Bioinformatics Resource Center funded by the National Institutes of Health, with additional support from the Welllcome Trust, VEuPathDB supports >500 organisms comprising invertebrate vectors, eukaryotic pathogens (protists and fungi) and relevant free-living or non-pathogenic species or hosts. Designed to empower researchers with access to Omics data and bioinformatic analyses, VEuPathDB projects integrate >1700 pre-analysed datasets (and associated metadata) with advanced search capabilities, visualizations, and analysis tools in a graphic interface. Diverse data types are analysed with standardized workflows including an in-house OrthoMCL algorithm for predicting orthology. Comparisons are easily made across datasets, data types and organisms in this unique data mining platform. A new site-wide search facilitates access for both experienced and novice users. Upgraded infrastructure and workflows support numerous updates to the web interface, tools, searches and strategies, and Galaxy workspace where users can privately analyse their own data. Forthcoming upgrades include cloud-ready application architecture, expanded support for the Galaxy workspace, tools for interrogating host-pathogen interactions, and improved interactions with affiliated databases (ClinEpiDB, MicrobiomeDB) and other scientific resources, and increased interoperability with the Bacterial & Viral BRC.

Tall buildings are one of the few constructed facilities whose design relies solely upon analytical and scaled models, which, though based upon fundamental mechanics and years of research and experience, has yet to be systematically validated in full scale. In response to this need, through the combined efforts of members of academe, a design firm and a commercial wind tunnel testing laboratory, a program was initiated to monitor the full-scale response of representative tall buildings and compare this to the predicted response from wind tunnels and finite-element models used commonly in design. As part of this monitoring program, in situ periods and damping ratios over a range of response amplitudes are also being evaluated. This paper provides an overview of the monitoring program, which includes three tall buildings in the city of Chicago, details their instrumentation and modeling, and provides an example of the full-scale response data analyses being conducted.

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This study introduces a unique prototype system for structural health monitoring (SHM), SmartSync, which uses the building's existing Internet backbone as a system of virtual instrumentation cables to permit modular and largely plug-and-play deployments. Within this framework, data streams from distributed heterogeneous sensors are pushed through network interfaces in real time and seamlessly synchronized and aggregated by a centralized server, which performs basic data acquisition, event triggering, and database management while also providing an interface for data visualization and analysis that can be securely accessed. The system enables a scalable approach to monitoring tall and complex structures that can readily interface a variety of sensors and data formats (analog and digital) and can even accommodate variable sampling rates. This study overviews the SmartSync system, its installation/operation in the world's tallest building, Burj Khalifa, and proof-of-concept in triggering under dual excitations (wind and earthquake).

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Despite many advances in the area of wind effects on structures in recent decades, research has been traditionally conducted within limited resources scattered geographically. With the trend toward increasingly complex designs of civil infrastructure combined with the escalating potential for losses by extreme wind events, a new culture of research needs to be established based on innovative and collaborative solutions for better management of the impact of extreme wind events. To address this change, this paper presents a new paradigm of a multiscale cyber-based laboratory framework for the analysis/ design, modeling, and simulation of wind load effects based on an ongoing collaborative cyberinfrastructure-based platform, Virtual Organization for Reducing the Toll of EXtreme Winds (VORTEX-Winds, https://vortex-winds.org), and discusses its current status since its inception in 2007 and ongoing developments. This collaborative framework as it evolves would enable a paradigm shift by offering advanced cyber-enabled modules (e-modules) for accelerating advances in research and education to achieve improved understanding and better modeling of wind effects on structures. Accordingly, it will enhance wind community's analysis and design capabilities to address next-gener ation challenges posed by wind. Through empowering those without computational or experimental resources, the e-modules will encompass a large set of subject areas and topics categorized as Database-enabled design, Full-scale/Field site data repository, Statistical/Stochastic toolboxes, Tele-experimentation, Uncertainty modeling, Damage assessment, and Computational platforms. This prototype will allow access to the individual e-module, while it is envisaged that next level of development in VORTEX-Winds will have the capability for an automated and integrated analysis/design through a nexus of e-modules. A highlight of the e-modules currently completed or in development is presented not only to show the efficacy of the framework to enhance and supplement the limitation of traditional off-line approaches but also to describe architecture and features of e-modules to promote additional cyber-enabled data-driven developments in the field.