Sorbus commixta is a tree of the Rosaceae family growing in Asia that has long been used to treat asthma and neuralgia. In a previous report, the chemical isolated from the bark of S. commixta was shown to suppress the production of nitric oxide (NO) and preinflammation by down regulating the NF-?B pathway in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Vitiligo is an acquired immune disease, usually characterized by white spots on the skin; however, its exact cause has not been identified. This study assessed the effects of an ethanol extract of S. commixta twigs (STE) on melanocyte activation, as well as its antiinflammatory and antioxidant properties. STE significantly increased the proliferation and melanin content of B16 melanocytes. Because of the importance of tumor necrosis factor (TNF)-? in inflammatory diseases, including the stimulation of vitiligo, the antiinflammatory effects of STE were tested in TNF-?-stimulated dermal fibroblasts and keratinocytes. STE reduced the levels of expression of IL-6, IL-8 and TNF- ? mRNA and proteins. To assess the underlying molecular mechanism, the effects of STE on the mitogen-activated protein kinase (MAPK) signaling process were analyzed in dermal fibroblasts. Results show that STE inactivated extracellular signal-regulated kinase (ERK). In addition, STE exhibited antioxidative properties in assays of DPPH radical scavenging activity. Taken together, these findings suggest that STE has potential therapeutic activity in vitiligo.
Background: Aroma oils have various psychological and physical effects and have been used in the beauty industry in several ways.Although aroma oils have functional effects regarding skin beauty, they are not fully utilized in the cosmetic marketing field.Objective: To bring out the potential of aroma oils in the market, the perception of efficacies of aroma oils and the evaluation of functional efficacy were studies and analyzed in this study. Methods:The awareness of the effects of aroma oils was determined using surveys, and the actual cosmetic effects of aroma oils were analyzed via in vitro tests.Results: As a result of evaluating the efficacy of aroma oils via experiments, basil, ylang-ylang, lemongrass, geranium, peppermint, and marjoram oils have antioxidant properties, and eucalyptus and lemongrass oils have brightening effects. Conclusion:Basil, ylang-ylang, lemongrass, geranium, peppermint, and marjoram oils have the potential to be used as ingredients in anti-aging cosmetics. Also, eucalyptus and lemongrass oils have brightening effects, indicating that they have potential as ingredients for brightening cosmetics.
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