A novel glycoprotein PLG-3 was obtained from the cultured mycelia of the edible mushroom Phellinus linteus AML1101 by isolating with cold water for 24 h and fractioned with DEAE-Sephrose Fast Flow column. It exhibited potent antiproliferative activity on A549 cells and HepG2 cells in vitro. After 24, 48, 72- h treatment with PLG-3, IC50 values of A549 cells and HepG2 cells were 45.77, 24.09, 16.54 μg/L and 47.78, 26.73, 18. μg/L, respectively. PLG-3 had a molecular weight of 2.5×104 Da, and consisted of approximately 85.5% of protein and 13.7% polysacchrides. It was composed of arabinose, xylose, mannose, glucose and galactose with a molar ratio of 1.46: 2.22: 7.74: 1.29:0.61.The obtained results proven that PLG-3 was a protein-dominant glycoprotein with singificant antiproliferative activity.
In our Research, we Used Cornus Wisoniana oil as Feedstock and the High Temperature Pyrolysis Kettle as the Reactor. Examine the Performance of Lanthanum Oxide, Zirconium Sulfate, Calcium Oxide and KF Loaded Catalyst on Cornus Wisoniana oil Catalytic Cracking Reaction. and through the SEM, XRD and FT-IR, Optimal Catalysts were Used to Characterize the Structure. the Results Showed that among KF Modified Catalyst KF Supported on Cao Produced Highest Yield of Bio-Fuel Oil from Cornus Wisoniana oil. when the Dosage of Catalyst Reached 1%, KF Impregnation Ratio of 40%, and Catalyst Calcination for 4h at 600°C, it can be Obtained Highest Yield of Bio-Fuel Oil about 82.7% and Reaction Rate up to 94.1. in Addition to the KF/MgO Having Low Yield about 60.6%, Catalytic Activity of other Four KF Catalysts were Higher than that of Lanthanum Oxide, Zirconium Sulfate and Calcium Oxide. the Catalytic Efficiency of Lanthanum Oxide and Zirconium Sulfate Appeared Similarity and are all Low. the Catalytic Activity of Calcium Oxide is Slightly Higher than the Lanthanum Oxide and Zirconium Sulfate, but Lower than that of KF/CaO Catalyst.
Objective. The levels of vitamin D, trace elements, and glucose and lipid metabolism in psoriasis were evaluated, and their value in disease diagnosis and severity evaluation was explored. Methods. In this study, the serum trace elements, blood glucose, and blood lipid indexes of 360 patients with psoriasis and 500 healthy subjects were compared and analyzed. Results. The results of 25-(OH) D3, Cu/Zn, and HDL-C in patients with psoriasis were significantly different from those in the control group. With the aggravation of the disease, Psoriasis Area and Severity Index (PASI) was positively correlated with 25-(OH) D3 and HDL-C and negatively correlated with Cu/Zn. The AUC of the three indexes for the diagnosis of psoriasis was 0.899, 0.675, and 0.848, respectively. Conclusion. There are metabolic abnormalities of 25-(OH) D3, Cu/Zn, and HDL-C in patients with psoriasis, and paying attention to these indicators is conducive to the diagnosis of disease.
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