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Spinal cord injury (SCI) is one of the most destructive diseases. The neuroinflammation microenvironment needs comprehensive mitigation of damages. Thus, regulation of local, microenvironment drugs could be a potential effective treatment. However, clinical studies on SCI with common treatment have reported it to cause systemic toxicity and side effects. Zinc oxide nanoparticles (ZnONPs) have been widely reported to have satisfying anti-inflammation function. Furthermore, green synthesis procedures can improve the capability and possible utilization of ZnONPs. However, the efficient administration and underlying mechanism of ZnONPs in SCI treatment remain unclear. Herein, an innovative approach was built by utilizing ZnONPs loaded in a skeletal muscle-derived adhesive hydrogel (ZnONPs-Gel). Different from the systemic application of ZnONPs, the local administration of ZnONPs-Gel offered the ZnONPs-loaded extracellular matrix with beneficial biocompatibility to the injured spinal cord, thereby promoting effective function recovery. Mechanistically, the ZnONPs-Gel treatment not only markedly reduced ROS production but also decreased apoptosis in the injured spinal cord. Therefore, the strategy based on local administration of the ZnONPs-Gel in the early stage of SCI may be an effective therapeutic treatment.

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A system is proposed for the high precision on -line verification of the miniature spring structure, including overall height, diameters of various coils as well as pitches between neighboring coils of the miniature conical springs. High precision measurements without physical contact and short processing time are achieved. Deformations of any kind on the conical springs can be identified even from the worst viewing direction. AbstractA system is proposed for the high precision on-line verification of the miniature spring structure, including overall height, diameters of various coils as well as pitches between neighboring coils of the miniature conical springs. High precision measurements without physical contact and short processing time are achieved. Deformations of any kind on the conical springs can be identified even from the worst viewing direction. /SPIEVol. 1153 Applications of Digital Image Processing XII (1989)Downloaded From: http://proceedings.spiedigitallibrary.org/ on 06/16/2016 Terms of Use: http://spiedigitallibrary.org/ss/TermsOfUse.aspx