Prodromal positive psychotic symptoms and anxiety are two strong risk factors for schizophrenia in 22q11.2 deletion syndrome (22q11DS). The analysis of large-scale brain network dynamics during rest is promising to investigate aberrant brain function and identify potentially more reliable biomarkers. We retrieved and examined dynamics of large-scale functional brain networks using innovation-driven co-activation patterns (iCAPs) and probed into functional signatures of prodromal psychotic symptoms and anxiety. Patients with 22q11DS had shorter activation in cognitive brain networks and longer activation in emotion processing networks. Functional signatures of prodromal psychotic symptoms confirmed an implication of cingulo-prefrontal salience network activation duration and coupling. Functional signatures of anxiety uncovered an implication of amygdala activation and coupling, indicating differential roles of dorsal and ventral sub-divisions of anterior cingulate and medial prefrontal cortices. These results confirm that the dynamic nature of brain network activation contains essential function to develop clinically relevant imaging markers of psychosis vulnerability.
SummaryAtypical deployment of social gaze is present early on in toddlers with autism spectrum disorders (ASDs). Yet, studies characterizing the developmental dynamic behind it are scarce. Here we used a data-driven method to delineate the developmental change in visual exploration of social interaction over childhood years in autism. Longitudinal eye-tracking data were acquired as children with ASD and their typically developing (TD) peers freely explored complex animated scene. We found divergent moment-to moment gaze patterns in children with ASD compared to their TD peers. This divergence was particularly evident in sequences that displayed social interactions between characters, and even more so in the children with lower developmental and functional levels. Basic visual properties of the animated scene did not accounted for the enhanced divergence. Over childhood years, these differences dramatically increased to become more idiosyncratic. Taken together, these findings suggest that social attention should be targeted early in clinical treatments.HighlightsA dynamic measure of divergence from normative gaze patterns was obtained while children with ASD watched animated cartoonThe degree of divergence was negatively associated with adaptive and cognitive functioningDuring childhood viewing patterns in children with ASD were increasingly idiosyncraticIncreased idiosyncrasy of gaze deployment in children with ASD characterized processing of sequences comprising social interaction
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