Progressive cerebellar and extrapyramidal motor disturbances are described in two 16-year-old female twins with classical galctosaemia. The neurological disturbances, characterized by hyper- and dysmetric movements and bilateral intention tremor with choreatic, atactic and even ballistic motor storms, appeared at 12 years of age. Computerized tomography demonstrates cerebral atrophy in cerebellar, brain stem and basal ganglia structures. The central conduction times, determined by somatosensible evoked potentials, are grossly prolonged; the peripheral nerve conduction velocities are normal. The neurological sequelae described are considered a distinct entity in the course of galactosaemia.

To investigate the age-dependency of central conduction time somatosensible evoked potentials to median nerve stimulation were recorded in 80 infants and children from the age of one week to 20 years. It is shown that the central conduction time starts at about 14 ms in the neonatal period and then gradually declines until the 7th or 8th year of life to the normal adult value with an upper limit of 7 ms. By dividing the data into several groups with age delimiters at 0.5, 1, 3, 5 and 7 years it shows significant differences of the mean values for the central conduction times according to the Student's t-test. The graph itself can well be approximated by the exponential regression y = 6.099 + 7.55 X e-0.686 X x where y represents the CCT and x the age in years. This slow maturation kinetic is presumably due to the ongoing central myelinisation.

The Fatalism and Social System Control dimensions of the Reid-Ware Three-Factor Locus of Control Scale were correlated with the two main factors of the Buss-Durkee Hostility-Aggression Inventory. For the total sample of 61 male and 96 female undergraduates, both locus of control dimensions correlated significantly with the Hostility factor. Externals on each dimension reported greater hostility than did internals. Only the Fatalism dimension correlated with the Aggression factor, with externals reporting more aggression than internals. For males, only the Fatalism dimension was significantly correlated with the Hostility factor. Both the Fatalism and Social System Control dimensions correlated with the Hostility factor among the females, but the correlation with the latter dimension was slightly stronger. Neither locus of control dimension was correlated significantly with the Aggression factor when data from males and females were analyzed separately.

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