Thin-Layer Chromatography of Darvon Compound-65A casual glance through any recent issue of this Journal reveals that more and more undergraduate laboratory experiments are being oriented toward drugs (1-5). Our organic laboratory experiments are also tending in that direction (6). In light of the new interests in Darvon (7), we decided that the thin-layer analysis of Darvon drugs would be appropriate.Darvon Compound-65, an effective analgesic, consists of four components (8): caffeine (I), phenacetin (II), aspirin (III), and propoxyphene hydrochloride (IV), itself known
Introducing students to thin-layer chromatography studies of commercial drugs is gaining more interest in the undergraduate laboratory. In view of this interest, we would like to report an experiment which the authors have developed along the same lines but which introduces a little more theory and technique.
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