Based on the analysis of a large volume of the literature data concerning simulation of thrombotic conditions in laboratory animals under experimental conditions, the authors discuss various models of venous thrombosis. The method proposed by S. Wessler et al. (1959) is considered to be the simplest, most readily reproducible, and least invasive one. It consists of a combination of venous hyperemia and hypercoagulation induced by the administration of an activated coagulation factor.
Summary. Research aim. To estimate efficiency of thromboclasis and anticoagulating therapy for patients with DVT of pelvis and lower limbs and to determine the severity of CVI caused by PTD in the long term.
Material and methods. 138 patients with thrombosis in the system of the inferior vena cava were examined and treated.
Results and discussion. Thrombolytic therapy (TLT) as a basic method of treatment was used in 52 (37.7 %) patients. 20 (14.5 %) patients undergone catheter-controlled thrombolysis(CCT) and 32 (23.2 %) patients had systemic thrombolytic therapy. 86 (62.3 %) patients in the basic treatment had anticoagulant therapy (ACT). In the long-term results of TLT significantly exceed the results of ACT. 70 % of these patients had signs of postthrombotic disease (PTD) with mild chronic venous insufficiency(CVI), and 100 % of patients with ACT had more severe forms of PTD.
Conclusions. Application of TLT for patients from with DVT of the pelvis and lower limbs resulted in rapid regress or complete removal of basic clinical signs of venous thrombosis. Instrumental methods of research, such as Doppler ultrasonography and color duplex scanning, as well as X-ray contrast phlebography are the only informative methods for assessing the process of dissolution of blood clots, the functional state of deep veins of the pelvis and lower limbs during CCT.
Summary. We studied the results of stationary and ambulatory surgical treatment of patients with deep vein thrombosis (DVT) of the lower extremities. A comparative analysis of clinical efficacy and safety of ambulatory and stationary modes of anticoagulant therapy of DVT. Based on this, marked indications for ambulatory surgical treatment of patients with DVT.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.