The diimine-dioxime ligand, 3,3′-(1,4-butanediyl-dinitrilo)bis-2--pentanone, 2,2′-dioxime (LH 2 ), containing a N 4 donor set was prepared by the Schiff base condensation of 2-hydroxyimino-3-pentanone and 1,4-diaminobutane in two ways: in a protic and in an aprotic solvent. A higher yield of the (LH 2 ) imine was obtained when the synthesis was performed using a protic solvent (C 2 H 5 OH) instead of aprotic benzene (78 and 30 %, respectively). The Cu(II) metal complex of diimine-dioxime was synthesized in CH 3 OH from the perchlorate salt of LH 2 in a 1:1 mole ratio. The isolated complex was characterized by the elemental analysis, IR spectroscopy and cyclic voltammetry. The structure of [Cu 2 (LH) 2 ](ClO 4 ) 2 was determined by single-crystal X-ray diffraction analysis. Comparison with structurally related diimine-dioxime Cu(II) complexes revealed the influence of a weak Cu … O(perchlorate) interaction on the geometry of the metallocycle.
The crystal and molecular structures of four tetrahedral structurally similar [Co(aamp) 2 X 2 ] complexes (aamp = 4-acetyl-3-amino-5-methylpyrazole, X = Cl, Br, I and NCS) were determined by X-ray diffraction analysis and are discussed in detail. It was found that the different capacity of the ligand X (NCS vs. Cl, Br, I) for the formation of non-bonding contacts influence the mode of molecular association in the solid state. The complexes were characterized by UV-Vis spectroscopy. The first step of the thermal decomposition of the compounds was checked and is discussed in the view of the IR spectrum of the intermediate isolated from [Co(aamp) 2 Br 2 ] by the quasi-isothermal technique.
Various factors and reasons can be responsible for acute, severe or protracted hemorrhages in the oral cavity. Hemostasis with conventional methods frequently poses a difficult, dangerous and involved problem. A special method is developed utilizing the chemical and physical properties of inorganic and organic compounds, and this is found to be efficient for rapid and safe hemostasis. It acts on the blood coagulation process by lowering the pH value of blood, as well as by its astringent and osmotic properties. Altogether, the result is hemostasis and favorable wound healing. With the use of bone cement, the initial clot is physically protected, thus contributing more to reliable hemostasis, particularly after dental extraction. The method used, that is, bone cement in combination with the developed hemostatic agent, can be used without additional treatment for severe primary, as well as secondary hemorrhages. Patients suffering from hemophilia and other disorders of blood coagulation were treated successfully.
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